CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033908
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disintegrin and metalloproteinase domain-containing protein 22 
Protein Synonyms/Alias
  
Gene Name
 Adam22 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
781SERIPDTKHISDICEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 897 AA 
Protein Sequence
MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 60
DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 120
GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 180
HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 240
LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 300
ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 360
TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 420
HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 480
SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 540
FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 600
LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 660
CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 720
TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 780
KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST EYLNPWFKRD YNVAKWVEDV 840
NKNTEGPYFR TLSPAKSPSS STGSIASSRK YPYPMPPLPD EGKTAGRQSA RLWETSI 897 
Gene Ontology
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR006586; ADAM_Cys-rich.
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR018358; Disintegrin_CS.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B.
 IPR002870; Peptidase_M12B_N. 
Pfam
 PF08516; ADAM_CR
 PF00200; Disintegrin
 PF01562; Pep_M12B_propep
 PF01421; Reprolysin 
SMART
 SM00608; ACR
 SM00050; DISIN
 SM00181; EGF 
PROSITE
 PS50215; ADAM_MEPRO
 PS00427; DISINTEGRIN_1
 PS50214; DISINTEGRIN_2
 PS00022; EGF_1
 PS50026; EGF_3 
PRINTS
 PR00289; DISINTEGRIN.