CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018527
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucokinase regulatory protein 
Protein Synonyms/Alias
 Glucokinase regulator 
Gene Name
 Gckr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
131LMKGLGQKPLYTYLIubiquitination[1]
164LHGIEELKKVAAGKKubiquitination[1]
239RMQKMQEKQEAFVLNubiquitination[1]
312VTYSQSSKIATLTKQubiquitination[1]
318SKIATLTKQVGISLEubiquitination[1]
531HVQVAHEKEKVIPTAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Inhibits glucokinase by forming an inactive complex with this enzyme (By similarity). 
Sequence Annotation
 DOMAIN 90 286 SIS 1.
 DOMAIN 320 476 SIS 2.  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 587 AA 
Protein Sequence
MPSTKRYQHV IETPEPGEWE LSGYEAAVPI TEKSNPLTRN LDKADAEKIV QLLGQCDAEI 60
FQEEGQIMPT YQRLYSESVL TTMLQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS 120
FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE RTEDSALHGI EELKKVAAGK KRVVVIGISV 180
GLSAPFVAGQ MDYCMDNTAV FLPVLVGFNP VSMARNDPIE DWRSTFRQVA ERMQKMQEKQ 240
EAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGVVSSQR CLLEILRTFE 300
RAHQVTYSQS SKIATLTKQV GISLEKKGHV HLVGWQTLGI IAIMDGVECI HTFGADFRDI 360
RGFLIGDHND MFNQKDELSN QGPQFTFSQD DFLTSVLPSL TEIDTVVFIF TLDDNLAEVQ 420
ALAERVREKS WNIQALVHST VGQSLPAPLK KLFPSLISIT WPLLFFDYEG SYVQKFQREL 480
STKWVLNTRF SGQSKARCIE SLLQVIHFPQ PLSNDVRAAP ISCHVQVAHE KEKVIPTALL 540
SLLLRCSITE AKERLAAASS VCEVVRSALS GPGQKRSIQA FGDPVVP 587 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0030246; F:carbohydrate binding; IEA:Compara.
 GO:0004857; F:enzyme inhibitor activity; IEA:Compara.
 GO:0070095; F:fructose-6-phosphate binding; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0001678; P:cellular glucose homeostasis; IMP:MGI.
 GO:0033132; P:negative regulation of glucokinase activity; IEA:Compara.
 GO:0033133; P:positive regulation of glucokinase activity; IMP:BHF-UCL.
 GO:0000060; P:protein import into nucleus, translocation; IMP:MGI.
 GO:0009750; P:response to fructose stimulus; IEA:Compara.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara.
 GO:0046415; P:urate metabolic process; IEA:Compara. 
Interpro
 IPR005486; Glucokinase_regulatory_CS.
 IPR001347; SIS. 
Pfam
  
SMART
  
PROSITE
 PS01272; GCKR
 PS51464; SIS 
PRINTS