CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033494
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cysteine synthase 
Protein Synonyms/Alias
  
Gene Name
 CBS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82KILPDILKKIGDTPMubiquitination[1]
102IGKKFGLKCELLAKCubiquitination[1]
119FNAGGSVKDRISLRMubiquitination[1]
137AERDGTLKPGDTIIEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 177 AA 
Protein Sequence
MPSETPQAEV GPTGCPHRSG PHSAKGSLEK GSPEDKEAKE PLWIRPDAPS RCTWQLGRPA 60
SESPHHHTAP AKSPKILPDI LKKIGDTPMV RINKIGKKFG LKCELLAKCE FFNAGGSVKD 120
RISLRMIEDA ERDGTLKPGD TIIEPTSGNT GIGLALAAAV RGYRCIIVMP EKMSSEK 177 
Gene Ontology
 GO:0004122; F:cystathionine beta-synthase activity; IEA:Compara.
 GO:0004124; F:cysteine synthase activity; IEA:EC.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0021587; P:cerebellum morphogenesis; IEA:Compara.
 GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
 GO:0001958; P:endochondral ossification; IEA:Compara.
 GO:0070814; P:hydrogen sulfide biosynthetic process; IEA:Compara.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0050880; P:regulation of blood vessel size; IEA:Compara.
 GO:0030823; P:regulation of cGMP metabolic process; IEA:Compara.
 GO:0043506; P:regulation of JUN kinase activity; IEA:Compara.
 GO:0051593; P:response to folic acid; IEA:Compara.
 GO:0006801; P:superoxide metabolic process; IEA:Compara.
 GO:0019346; P:transsulfuration; IEA:Compara. 
Interpro
 IPR001216; Cys_synth_BS.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 
Pfam
 PF00291; PALP 
SMART
  
PROSITE
 PS00901; CYS_SYNTHASE 
PRINTS