CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000033
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metabotropic glutamate receptor 8 
Protein Synonyms/Alias
 mGluR8 
Gene Name
 GRM8 
Gene Synonyms/Alias
 GPRC1H; MGLUR8 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
882DRPNGEVKSELCESLsumoylation[1]
903SVEFPMVKSGSTS**sumoylation[1]
Reference
 [1] SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.
 Dütting E, Schröder-Kress N, Sticht H, Enz R.
 Biochem J. 2011 Apr 15;435(2):365-71. [PMID: 21288202
Functional Description
 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. 
Sequence Annotation
 CARBOHYD 95 95 N-linked (GlcNAc...) (Potential).
 CARBOHYD 298 298 N-linked (GlcNAc...) (Potential).
 CARBOHYD 452 452 N-linked (GlcNAc...) (Potential).
 CARBOHYD 480 480 N-linked (GlcNAc...) (Potential).
 CARBOHYD 565 565 N-linked (GlcNAc...) (Potential).
 DISULFID 64 106 By similarity.
 DISULFID 246 534 By similarity.
 DISULFID 369 384 By similarity.
 DISULFID 424 431 By similarity.
 DISULFID 516 535 By similarity.
 DISULFID 520 538 By similarity.
 DISULFID 541 553 By similarity.
 DISULFID 556 569 By similarity.
 CROSSLNK 882 882 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Isopeptide bond; Membrane; Olfaction; Polymorphism; Receptor; Reference proteome; Sensory transduction; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 908 AA 
Protein Sequence
MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG LFPVHAKGER 60
GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV RILDTCSRDT YALEQSLTFV 120
QALIEKDASD VKCANGDPPI FTKPDKISGV IGAAASSVSI MVANILRLFK IPQISYASTA 180
PELSDNTRYD FFSRVVPPDS YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR 240
EIGGVCIAQS QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 300
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL ANNRRNVWFA 360
EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG KVQFVIDAVY SMAYALHNMH 420
KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN FNGSAGTPVT FNENGDAPGR YDIFQYQITN 480
KSTEYKVIGH WTNQLHLKVE DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER 540
CEGYNYQVDE LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF 600
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF RRVFLGLGMC 660
FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF SLISVQLLGV FVWFVVDPPH 720
IIIDYGEQRT LDPEKARGVL KCDISDLSLI CSLGYSILLM VTCTVYAIKT RGVPETFNEA 780
KPIGFTMYTT CIIWLAFIPI FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI 840
IIFHPEQNVQ KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNSKSSVEFP 900
MVKSGSTS 908 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004930; F:G-protein coupled receptor activity; TAS:UniProtKB.
 GO:0008066; F:glutamate receptor activity; TAS:UniProtKB.
 GO:0001642; F:group III metabotropic glutamate receptor activity; IEA:Compara.
 GO:0007194; P:negative regulation of adenylate cyclase activity; TAS:ProtInc.
 GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; TAS:ProtInc. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR000337; GPCR_3.
 IPR011500; GPCR_3_9-Cys_dom.
 IPR017978; GPCR_3_C.
 IPR017979; GPCR_3_CS.
 IPR000162; GPCR_3_mtglu_rcpt.
 IPR000144; GPCR_3_mtglu_rcpt_8. 
Pfam
 PF00003; 7tm_3
 PF01094; ANF_receptor
 PF07562; NCD3G 
SMART
  
PROSITE
 PS00979; G_PROTEIN_RECEP_F3_1
 PS00980; G_PROTEIN_RECEP_F3_2
 PS00981; G_PROTEIN_RECEP_F3_3
 PS50259; G_PROTEIN_RECEP_F3_4 
PRINTS
 PR00248; GPCRMGR.
 PR01058; MTABOTROPC8R.
 PR00593; MTABOTROPICR.