UniProt Accession

 MAP2_YEAST; P38174; D6VPR3; P89493 

Genbank Protein ID

 U17437; X79489; Z35851; Z35852; BK006936 

Genbank Nucleotide ID

 AAC49142.1; CAA56011.1; CAA84912.1; CAA84913.1; DAA07033.2 

Protein Name

 Methionine aminopeptidase 2 

Protein Synonyms/Alias

 MAP 2; MetAP 2; Peptidase M 

Gene Name

 MAP2 

Gene Synonyms/Alias

 YBL091C; YBL0701 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
347	DSAKNLLKTIDRNFG	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays only a minor role in N-terminal methionine removal. Less efficient when the second residue is Val, Gly, Cys or Thr. 

Sequence Annotation

 METAL 194 194 Divalent metal cation 1 (By similarity).
 METAL 205 205 Divalent metal cation 1 (By similarity).
 METAL 205 205 Divalent metal cation 2; catalytic (By
 METAL 274 274 Divalent metal cation 2; catalytic; via
 METAL 307 307 Divalent metal cation 2; catalytic (By
 METAL 402 402 Divalent metal cation 1 (By similarity).
 METAL 402 402 Divalent metal cation 2; catalytic (By
 BINDING 174 174 Substrate (By similarity).
 BINDING 282 282 Substrate (By similarity).
 MOD_RES 35 35 Phosphoserine.  

Keyword

 Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Phosphoprotein; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 421 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0070006; F:metalloaminopeptidase activity; IGI:SGD.
 GO:0035551; P:protein initiator methionine removal involved in protein maturation; IMP:SGD.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001714; Pept_M24_MAP.
 IPR000994; Pept_M24_structural-domain.
 IPR002468; Pept_M24A_MAP2.
 IPR018349; Pept_M24A_MAP2_BS.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00557; Peptidase_M24 

SMART

  

PROSITE

 PS01202; MAP_2 

PRINTS

 PR00599; MAPEPTIDASE.