UniProt Accession

 RL44A_YEAST; P0CX27; D3DL90; P02405 

Genbank Protein ID

 D10578; X92517; Z71438; BK006947 

Genbank Nucleotide ID

 BAA01435.1; CAA63277.1; CAA96049.1; DAA10387.1 

Protein Name

 60S ribosomal protein L42-A 

Protein Synonyms/Alias

 L41; YL27; YP44 

Gene Name

 RPL42A 

Gene Synonyms/Alias

 RPL41A; SCL41A; YNL162W; N1722 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
24	CRKHTQHKVTQYKAG	acetylation	[1]
24	CRKHTQHKVTQYKAG	ubiquitination	[2]
29	QHKVTQYKAGKASLF	ubiquitination	[2]
40	ASLFAQGKRRYDRKQ	methylation	[3, 4]
55	SGFGGQTKPVFHKKA	methylation	[3, 4]
76	VLRLECVKCKTRAQL	ubiquitination	[2]
89	QLTLKRCKHFELGGE	acetylation	[1]
97	HFELGGEKKQKGQAL	acetylation	[1]
100	LGGEKKQKGQALQF*	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab.
 Webb KJ, Laganowsky A, Whitelegge JP, Clarke SG.
 J Biol Chem. 2008 Dec 19;283(51):35561-8. [PMID: 18957409]
 [4] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

  

Sequence Annotation

 MOD_RES 40 40 N6-methyllysine; by RKM3.
 MOD_RES 55 55 N6-methyllysine; by RKM4.  

Keyword

 3D-structure; Antibiotic resistance; Complete proteome; Cycloheximide resistance; Cytoplasm; Direct protein sequencing; Methylation; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 106 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; TAS:SGD.
 GO:0003735; F:structural constituent of ribosome; TAS:SGD.
 GO:0002181; P:cytoplasmic translation; TAS:SGD.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
 GO:0046898; P:response to cycloheximide; IEA:UniProtKB-KW. 

Interpro

 IPR000552; Ribosomal_L44e.
 IPR011332; Ribosomal_zn-bd_dom. 

Pfam

 PF00935; Ribosomal_L44 

SMART

  

PROSITE

 PS01172; RIBOSOMAL_L44E 

PRINTS