UniProt Accession

 SSBP3_HUMAN; Q9BWW4; A8K0A9; Q5T860; Q5T861; Q9BTM0; Q9BWW3 

Genbank Protein ID

 AY026310; AY026293; AY026294; AY026295; AY026296; AY026297; AY026298; AY026299; AY026300; AY026301; AY026302; AY026303; AY026304; AY026305; AY026306; AY026307; AY026308; AY026309; AY026310; AY026293; AY026294; AY026295; AY026296; AY026297; AY026299; AY026300; AY026301; AY026302; AY026303; AY026304; AY026305; AY026306; AY026307; AY026308; AY026309; AF500116; AK289474; CH471059; AL035415; AL161644; AL035415; AL161644; AL161644; AL035415; AL161644; AL035415; BC003605; BC066365 

Genbank Nucleotide ID

 AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21984.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAK21985.1; AAM22101.1; BAF82163.1; EAX06692.1; CAI22487.1; CAI22487.1; CAI22488.1; CAI22488.1; CAI23562.1; CAI23562.1; CAI23563.1; CAI23563.1; AAH03605.1; AAH66365.1 

Protein Name

 Single-stranded DNA-binding protein 3 

Protein Synonyms/Alias

 Sequence-specific single-stranded-DNA-binding protein 

Gene Name

 SSBP3 

Gene Synonyms/Alias

 SSDP; SSDP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MFAKGKGSAVP	ubiquitination	[1]
6	**MFAKGKGSAVPSD	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region (By similarity). 

Sequence Annotation

 DOMAIN 16 48 LisH.
 MOD_RES 347 347 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 360 360 Phosphothreonine.
 MOD_RES 381 381 Phosphoserine.
 MOD_RES 387 387 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 388 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
 GO:0060323; P:head morphogenesis; IEA:Compara.
 GO:0021547; P:midbrain-hindbrain boundary initiation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:2000744; P:positive regulation of anterior head development; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0021501; P:prechordal plate formation; IEA:Compara.
 GO:0006461; P:protein complex assembly; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR006594; LisH_dimerisation.
 IPR008116; SSDP_DNA-bd.
 IPR007591; SSDP_ss-bd. 

Pfam

 PF04503; SSDP 

SMART

 SM00667; LisH 

PROSITE

 PS50896; LISH 

PRINTS

 PR01743; SSDNABINDING.