CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030707
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-2 
Protein Synonyms/Alias
 cDNA FLJ51799, highly similar to Sorting nexin-2 
Gene Name
 SNX2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
80LHSKLASKYLHVGYIubiquitination[1]
94IVPPAPEKSIVGMTKubiquitination[1]
101KSIVGMTKVKVGKEDubiquitination[1]
117SSTEFVEKRRAALERacetylation[2]
117SSTEFVEKRRAALERubiquitination[1]
131RYLQRTVKHPTLLQDubiquitination[1, 2, 3]
170GILRMVNKAADAVNKubiquitination[1]
192SDAWFEEKQQQFENLubiquitination[4]
229ANTAAFAKSAAMLGNubiquitination[4]
370KERVKDFKTVIIKYLacetylation[5]
399EAFLPEAKAIA****ubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 402 AA 
Protein Sequence
MSAPVIFDRS REEIEEEANG DIFDIEIGVS DPEKVGDGMN AYMAYRVTTK TSLSMFSKSE 60
FSVKRRFSDF LGLHSKLASK YLHVGYIVPP APEKSIVGMT KVKVGKEDSS STEFVEKRRA 120
ALERYLQRTV KHPTLLQDPD LRQFLESSEL PRAVNTQALS GAGILRMVNK AADAVNKMTI 180
KMNESDAWFE EKQQQFENLD QQLRKLHVSV EALVCHRKEL SANTAAFAKS AAMLGNSEDH 240
TALSRALSQL AEVEEKIDQL HQEQAFADFY MFSELLSDYI RLIAAVKGVF DHRMKCWQKW 300
EDAQITLLKK REAEAKMMVA NKPDKIQQAK NEIREWEAKV QQGERDFEQI SKTIRKEVGR 360
FEKERVKDFK TVIIKYLESL VQTQQQLIKY WEAFLPEAKA IA 402 
Gene Ontology
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro. 
Interpro
 IPR001683; Phox.
 IPR015404; Vps5_C. 
Pfam
 PF00787; PX
 PF09325; Vps5 
SMART
 SM00312; PX 
PROSITE
 PS50195; PX 
PRINTS