CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006733
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine hydroxymethyltransferase, mitochondrial 
Protein Synonyms/Alias
 SHMT; Glycine hydroxymethyltransferase; Serine methylase 
Gene Name
 SHM1 
Gene Synonyms/Alias
 SHMT1; YBR263W; YBR1732 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
52QQERHRQKHSITLIPacetylation[1]
98GGNEIIDKSESLCQAacetylation[1]
289KSVTKKGKEIPYELEacetylation[1]
297EIPYELEKKINFSVFacetylation[1]
400KNTIPGDKSALFPSGacetylation[1]
437KYIDSAVKLAENLKTacetylation[1]
443VKLAENLKTLEPTTKacetylation[1]
450KTLEPTTKLDARSRLacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Interconversion of serine and glycine. 
Sequence Annotation
 MOD_RES 265 265 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Complete proteome; Mitochondrion; One-carbon metabolism; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 490 AA 
Protein Sequence
MFPRASALAK CMATVHRRGL LTSGAQSLVS KPVSEGDPEM FDILQQERHR QKHSITLIPS 60
ENFTSKAVMD LLGSELQNKY SEGYPGERYY GGNEIIDKSE SLCQARALEL YGLDPAKWGV 120
NVQPLSGAPA NLYVYSAIMN VGERLMGLDL PDGGHLSHGY QLKSGTPISF ISKYFQSMPY 180
HVDHTTGLID YDNLQVLAKA FRPKVIVAGT SAYSRLIDYA RFKEISQGCG AYLMSDMAHI 240
SGLVAANVVP SPFEHSDIVT TTTHKSLRGP RGAMIFFRKG IKSVTKKGKE IPYELEKKIN 300
FSVFPGHQGG PHNHTIGAMA VALKQAMSPE FKEYQQKIVD NSKWFAQELT KMGYKLVSGG 360
TDNHLIVIDL SGTQVDGARV ETILSALNIA ANKNTIPGDK SALFPSGLRI GTPAMTTRGF 420
GREEFSQVAK YIDSAVKLAE NLKTLEPTTK LDARSRLNEF KKLCNESSEV AALSGEISKW 480
VGQYPVPGDI 490 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0004372; F:glycine hydroxymethyltransferase activity; IMP:SGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006544; P:glycine metabolic process; IEA:InterPro.
 GO:0006563; P:L-serine metabolic process; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IMP:SGD.
 GO:0009070; P:serine family amino acid biosynthetic process; IGI:SGD.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 
Interpro
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase.
 IPR019798; Ser_HO-MeTrfase_PLP_BS. 
Pfam
 PF00464; SHMT 
SMART
  
PROSITE
 PS00096; SHMT 
PRINTS