CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bardet-Biedl syndrome 10 protein 
Protein Synonyms/Alias
  
Gene Name
 BBS10 
Gene Synonyms/Alias
 C12orf58 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
40GRQVLCTKPTGEVLLubiquitination[1, 2, 3]
161LSIFSSAKERTLCRSubiquitination[2]
372TALVKFCKPLILRSKubiquitination[2]
477QDTVAENKDALEKTQubiquitination[4]
482ENKDALEKTQTYLKVubiquitination[4]
542DYYEPLLKNNSTAYSubiquitination[2, 3, 4]
713TVKRHPQKVHNQDSEubiquitination[2]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. 
Sequence Annotation
  
Keyword
 ATP-binding; Bardet-Biedl syndrome; Cell projection; Chaperone; Ciliopathy; Complete proteome; Disease mutation; Mental retardation; Nucleotide-binding; Obesity; Polymorphism; Reference proteome; Sensory transduction; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 723 AA 
Protein Sequence
MLSSMAAAGS VKAALQVAEV LEAIVSCCVG PEGRQVLCTK PTGEVLLSRN GGRLLEALHL 60
EHPIARMIVD CVSSHLKKTG DGAKTFIIFL CHLLRGLHAI TDREKDPLMC ENIQTHGRHW 120
KNCSRWKFIS QALLTFQTQI LDGIMDQYLS RHFLSIFSSA KERTLCRSSL ELLLEAYFCG 180
RVGRNNHKFI SQLMCDYFFK CMTCKSGIGV FELVDDHFVE LNVGVTGLPV SDSRIIAGLV 240
LQKDFSVYRP ADGDMRMVIV TETIQPLFST SGSEFILNSE AQFQTSQFWI MEKTKAIMKH 300
LHSQNVKLLI SSVKQPDLVS YYAGVNGISV VECLSSEEVS LIRRIIGLSP FVPPQAFSQC 360
EIPNTALVKF CKPLILRSKR YVHLGLISTC AFIPHSIVLC GPVHGLIEQH EDALHGALKM 420
LRQLFKDLDL NYMTQTNDQN GTSSLFIYKN SGESYQAPDP GNGSIQRPYQ DTVAENKDAL 480
EKTQTYLKVH SNLVIPDVEL ETYIPYSTPT LTPTDTFQTV ETLTCLSLER NRLTDYYEPL 540
LKNNSTAYST RGNRIEISYE NLQVTNITRK GSMLPVSCKL PNMGTSQSYL SSSMPAGCVL 600
PVGGNFEILL HYYLLNYAKK CHQSEETMVS MIIANALLGI PKVLYKSKTG KYSFPHTYIR 660
AVHALQTNQP LVSSQTGLES VMGKYQLLTS VLQCLTKILT IDMVITVKRH PQKVHNQDSE 720
DEL 723 
Gene Ontology
 GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0044267; P:cellular protein metabolic process; IEA:InterPro.
 GO:0051131; P:chaperone-mediated protein complex assembly; IMP:MGI.
 GO:0035058; P:nonmotile primary cilium assembly; IMP:BHF-UCL.
 GO:0045494; P:photoreceptor cell maintenance; IMP:BHF-UCL.
 GO:0043254; P:regulation of protein complex assembly; IMP:MGI.
 GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
 GO:0001895; P:retina homeostasis; IMP:BHF-UCL. 
Interpro
 IPR002423; Cpn60/TCP-1.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
  
PRINTS