UniProt Accession

 LUM_RAT; P51886 

Genbank Protein ID

 X84039; BC061878 

Genbank Nucleotide ID

 CAA58858.1; AAH61878.1 

Protein Name

 Lumican 

Protein Synonyms/Alias

 Keratan sulfate proteoglycan lumican; KSPG lumican 

Gene Name

 Lum 

Gene Synonyms/Alias

 Lcn; Ldc 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
69	PMVPPGIKYLYLRNN	acetylation	[1]
114	IKGKVFSKLKQLKKL	acetylation	[1]
148	DLQLANNKISKLGSF	acetylation	[1]
181	EAVSASLKGLKSLEY	acetylation	[1]
184	SASLKGLKSLEYLDL	acetylation	[1]
285	NYYLEVNKLEKFDVK	acetylation	[1]
288	LEVNKLEKFDVKSFC	acetylation	[1]
305	LGPLSYSKIKHLRLD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 DOMAIN 28 66 LRRNT.
 REPEAT 67 88 LRR 1.
 REPEAT 91 114 LRR 2.
 REPEAT 117 137 LRR 3.
 REPEAT 138 159 LRR 4.
 REPEAT 160 181 LRR 5.
 REPEAT 185 205 LRR 6.
 REPEAT 206 227 LRR 7.
 REPEAT 230 250 LRR 8.
 REPEAT 255 276 LRR 9.
 REPEAT 277 296 LRR 10.
 REPEAT 305 326 LRR 11.
 MOD_RES 19 19 Pyrrolidone carboxylic acid (By
 MOD_RES 20 20 Sulfotyrosine (By similarity).
 MOD_RES 21 21 Sulfotyrosine (By similarity).
 MOD_RES 23 23 Sulfotyrosine (By similarity).
 MOD_RES 30 30 Sulfotyrosine (By similarity).
 CARBOHYD 88 88 N-linked (GlcNAc...) (keratan sulfate)
 CARBOHYD 127 127 N-linked (GlcNAc...) (keratan sulfate)
 CARBOHYD 160 160 N-linked (GlcNAc...) (keratan sulfate)
 CARBOHYD 252 252 N-linked (GlcNAc...) (keratan sulfate)
 DISULFID 295 328 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Leucine-rich repeat; Proteoglycan; Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal; Sulfation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 338 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005583; C:fibrillar collagen; IEA:Compara.
 GO:0005578; C:proteinaceous extracellular matrix; IDA:RGD.
 GO:0051216; P:cartilage development; IEP:RGD.
 GO:0030199; P:collagen fibril organization; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0070848; P:response to growth factor stimulus; IEP:RGD.
 GO:0014070; P:response to organic cyclic compound; IEP:RGD.
 GO:0007601; P:visual perception; IEA:InterPro. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N.
 IPR027219; Lumican. 

Pfam

 PF01462; LRRNT 

SMART

 SM00369; LRR_TYP
 SM00013; LRRNT 

PROSITE

 PS51450; LRR 

PRINTS