UniProt Accession

 K7EQH5_HUMAN; K7EQH5 

Genbank Protein ID

 AC005944; CH471139 

Genbank Nucleotide ID

 EAW69341.1 

Protein Name

 Amino-terminal enhancer of split 

Protein Synonyms/Alias

 Amino-terminal enhancer of split, isoform CRA_a 

Gene Name

 AES 

Gene Synonyms/Alias

 hCG_2005178 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	LGAIERAKQVTAPEL	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 141 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0031668; P:cellular response to extracellular stimulus; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0040008; P:regulation of growth; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0001501; P:skeletal system development; IEA:Compara. 

Interpro

 IPR005617; Groucho/TLE_N. 

Pfam

 PF03920; TLE_N 

SMART

  

PROSITE

  

PRINTS