UniProt Accession

 ROAA_HUMAN; Q99729; B3KNN5; D3DWP7; Q04150; Q8N7U3; Q9BQ99 

Genbank Protein ID

 M65028; U76713; AK054600; AK097657; CH471165; CH471165; CH471165; BC001616; BC002625; BC004561; BC009359; BC036708 

Genbank Nucleotide ID

 AAA36575.1; AAC50956.1; BAG51397.1; BAC05134.1; EAW53843.1; EAW53844.1; EAW53845.1; AAH01616.1; AAH02625.1; AAH04561.1; AAH09359.1; AAH36708.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein A/B 

Protein Synonyms/Alias

 hnRNP A/B; APOBEC1-binding protein 1; ABBP-1 

Gene Name

 HNRNPAB 

Gene Synonyms/Alias

 ABBP1; HNRPAB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	GLSWDTSKKDLKDYF	ubiquitination	[1, 2, 3]
84	LSWDTSKKDLKDYFT	ubiquitination	[2]
92	DLKDYFTKFGEVVDC	ubiquitination	[1, 2]
102	EVVDCTIKMDPNTGR	ubiquitination	[2, 3]
119	GFGFILFKDAASVEK	ubiquitination	[2]
150	KKAMAMKKDPVKKIF	ubiquitination	[3]
169	NPEATEEKIREYFGE	ubiquitination	[2]
232	EIKVAQPKEVYQQQQ	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. 

Sequence Annotation

 DOMAIN 69 154 RRM 1.
 DOMAIN 153 233 RRM 2.
 MOD_RES 77 77 Phosphoserine (By similarity).
 MOD_RES 242 242 Phosphoserine.
 MOD_RES 245 245 Dimethylated arginine; alternate.
 MOD_RES 245 245 Omega-N-methylarginine; alternate.
 MOD_RES 322 322 Dimethylated arginine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:HGNC.
 GO:0005634; C:nucleus; ISS:HGNC.
 GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB.
 GO:0003729; F:mRNA binding; TAS:ProtInc.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0001837; P:epithelial to mesenchymal transition; ISS:HGNC.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:HGNC. 

Interpro

 IPR012956; CARG-binding_factor_N.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF08143; CBFNT
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS