Tag | Content |
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CPLM ID | CPLM-014500 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Contactin-1 |
Protein Synonyms/Alias | Neural cell surface protein F3 |
Gene Name | Cntn1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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955 | PDGQHDGKLFSTHKH | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. |
Sequence Annotation | DOMAIN 41 131 Ig-like C2-type 1. DOMAIN 137 223 Ig-like C2-type 2. DOMAIN 241 326 Ig-like C2-type 3. DOMAIN 331 407 Ig-like C2-type 4. DOMAIN 413 500 Ig-like C2-type 5. DOMAIN 504 603 Ig-like C2-type 6. DOMAIN 605 701 Fibronectin type-III 1. DOMAIN 708 805 Fibronectin type-III 2. DOMAIN 810 901 Fibronectin type-III 3. DOMAIN 906 998 Fibronectin type-III 4. LIPID 1001 1001 GPI-anchor amidated serine (Potential). CARBOHYD 208 208 N-linked (GlcNAc...) (Potential). CARBOHYD 258 258 N-linked (GlcNAc...) (Potential). CARBOHYD 338 338 N-linked (GlcNAc...) (Potential). CARBOHYD 457 457 N-linked (GlcNAc...) (Potential). CARBOHYD 473 473 N-linked (GlcNAc...) (Potential). CARBOHYD 494 494 N-linked (GlcNAc...) (Potential). CARBOHYD 521 521 N-linked (GlcNAc...) (Potential). CARBOHYD 593 593 N-linked (GlcNAc...) (Potential). CARBOHYD 935 935 N-linked (GlcNAc...) (Potential). DISULFID 65 114 By similarity. DISULFID 158 211 By similarity. DISULFID 263 310 By similarity. DISULFID 352 391 By similarity. DISULFID 436 484 By similarity. DISULFID 526 585 By similarity. |
Keyword | Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Notch signaling pathway; Reference proteome; Repeat; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1021 AA |
Protein Sequence | MKTPLLVSHL LLISLTSCLG EFTWHRRYGH GVSEEDKGFG PIFEEQPINT IYPEESLEGK 60 VSLNCRARAS PFPVYKWRMN NGDVDLTNDR YSMVGGNLVI NNPDKQKDAG IYYCLASNNY 120 GMVRSTEATL SFGYLDPFPP EDRPEVKVKE GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF 180 ITMDKRRFVS QTNGNLYIAN VESSDRGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY 240 PADIVVQFKD IYTMMGQNVT LECFALGNPV PDIRWRKVLE PMPTTAEIST SGAVLKIFNI 300 QLEDEGLYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW PCVATGKPIP 360 TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENAYGTI YANAELKILA LAPTFEMNPM 420 KKKILAAKGG RVIIECKPKA APKPKFSWSK GTEWLVNSSR ILIWEDGSLE INNITRNDGG 480 IYTCFAENNR GKANSTGTLV ITNPTRIILA PINADITVGE NATMQCAASF DPSLDLTFVW 540 SFNGYVIDFN KEITNIHYQR NFMLDANGEL LIRNAQLKHA GRYTCTAQTI VDNSSASADL 600 VVRGPPGPPG GLRIEDIRAT SVALTWSRGS DNHSPISKYT IQTKTILSDD WKDAKTDPPI 660 IEGNMESAKA VDLIPWMEYE FRVVATNTLG TGEPSIPSNR IKTDGAAPNV APSDVGGGGG 720 TNRELTITWA PLSREYHYGN NFGYIVAFKP FDGEEWKKVT VTNPDTGRYV HKDETMTPST 780 AFQVKVKAFN NKGDGPYSLI AVINSAQDAP SEAPTEVGVK VLSSSEISVH WKHVLEKIVE 840 SYQIRYWAGH DKEAAAHRVQ VTSQEYSARL ENLLPDTQYF IEVGACNSAG CGPSSDVIET 900 FTRKAPPSQP PRIISSVRSG SRYIITWDHV VALSNESTVT GYKILYRPDG QHDGKLFSTH 960 KHSIEVPIPR DGEYVVEVRA HSDGGDGVVS QVKISGVSTL SSGLLSLLLP SLGFLVFYSE 1020 F 1021 |
Gene Ontology | GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0030246; F:carbohydrate binding; IEA:Compara. GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. GO:0021549; P:cerebellum development; IEA:Compara. GO:0031175; P:neuron projection development; IEA:Compara. GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW. GO:0010628; P:positive regulation of gene expression; IEA:Compara. GO:0010976; P:positive regulation of neuron projection development; IEA:Compara. GO:0010765; P:positive regulation of sodium ion transport; IEA:Compara. |
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