UniProt Accession

 D3YUF2_MOUSE; D3YUF2 

Genbank Protein ID

 AC090881; AC166575 

Genbank Nucleotide ID

  

Protein Name

 Cysteine synthase 

Protein Synonyms/Alias

  

Gene Name

 Cbs 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
25	HLDMHSEKRQLEKGP	ubiquitination	[1]
30	SEKRQLEKGPSGDKD	ubiquitination	[1]
69	HYHTVLTKSPKILPD	ubiquitination	[1]
72	TVLTKSPKILPDILR	ubiquitination	[1]
80	ILPDILRKIGNTPMV	ubiquitination	[1]
116	FNAGGSVKDRISLRM	ubiquitination	[1]
134	AERAGNLKPGDTIIE	ubiquitination	[1]
158	LALAAAVKGYRCIIV	ubiquitination	[1]
169	CIIVMPEKMSMEKVD	ubiquitination	[1]
174	PEKMSMEKVDVLRAL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0004122; F:cystathionine beta-synthase activity; IMP:MGI.
 GO:0004124; F:cysteine synthase activity; IEA:EC.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0072341; F:modified amino acid binding; IEA:Compara.
 GO:0030170; F:pyridoxal phosphate binding; IEA:Compara.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0001974; P:blood vessel remodeling; IMP:MGI.
 GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IMP:MGI.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0021587; P:cerebellum morphogenesis; IMP:MGI.
 GO:0019344; P:cysteine biosynthetic process; IMP:MGI.
 GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
 GO:0001958; P:endochondral ossification; IMP:MGI.
 GO:0043418; P:homocysteine catabolic process; IEA:Compara.
 GO:0050667; P:homocysteine metabolic process; IMP:MGI.
 GO:0070814; P:hydrogen sulfide biosynthetic process; IEA:Compara.
 GO:0019448; P:L-cysteine catabolic process; IEA:Compara.
 GO:0006565; P:L-serine catabolic process; IEA:Compara.
 GO:0060135; P:maternal process involved in female pregnancy; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0050880; P:regulation of blood vessel size; IMP:MGI.
 GO:0030823; P:regulation of cGMP metabolic process; IMP:MGI.
 GO:0043506; P:regulation of JUN kinase activity; IMP:MGI.
 GO:0051593; P:response to folic acid; IMP:MGI.
 GO:0006801; P:superoxide metabolic process; IMP:MGI.
 GO:0019346; P:transsulfuration; IEA:Compara. 

Interpro

 IPR001216; Cys_synth_BS.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 

Pfam

 PF00291; PALP 

SMART

  

PROSITE

 PS00901; CYS_SYNTHASE 

PRINTS