UniProt Accession

 ALDR_MOUSE; P45376; O70130; Q99KC9 

Genbank Protein ID

 D32250; L39795; U29152; U89150; U89140; U89142; U89143; U89144; U89145; U89146; U89147; U89148; U89149; U93231; U93230; AB016665; BC004725; BC021655 

Genbank Nucleotide ID

 BAA06980.1; AAA62176.1; AAA69958.1; AAC13358.1; AAC13358.1; AAC13358.1; AAC13358.1; AAC13358.1; AAC13358.1; AAC13358.1; AAC13358.1; AAC13358.1; AAC13358.1; AAD32300.1; AAD32300.1; BAA76413.1; AAH04725.1; AAH21655.1 

Protein Name

 Aldose reductase 

Protein Synonyms/Alias

 AR; Aldehyde reductase 

Gene Name

 Akr1b1 

Gene Synonyms/Alias

 Akr1b3; Aldor1; Aldr1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
12	LELNNGTKMPTLGLG	ubiquitination	[1]
179	NKPGLKYKPAVNQIE	acetylation	[2]
179	NKPGLKYKPAVNQIE	ubiquitination	[1]
195	HPYLTQEKLIEYCHS	acetylation	[2]
222	SPDRPWAKPEDPSLL	acetylation	[3]
222	SPDRPWAKPEDPSLL	ubiquitination	[1]
240	RIKAIAAKYNKTTAQ	acetylation	[2]
243	AIAAKYNKTTAQVLI	acetylation	[2]
263	RNLVVIPKSVTPVRI	acetylation	[2]
263	RNLVVIPKSVTPVRI	ubiquitination	[1]
306	CALMSCAKHKDYPFH	acetylation	[2]
308	LMSCAKHKDYPFHAE	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. 

Sequence Annotation

 NP_BIND 10 19 NADP (Potential).
 NP_BIND 211 273 NADP (By similarity).
 ACT_SITE 49 49 Proton donor (By similarity).
 BINDING 111 111 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 222 222 N6-acetyllysine (By similarity).
 MOD_RES 263 263 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:MGI.
 GO:0043795; F:glyceraldehyde oxidoreductase activity; IEA:Compara.
 GO:0044597; P:daunorubicin metabolic process; IEA:Compara.
 GO:0044598; P:doxorubicin metabolic process; IEA:Compara. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS

 PR00069; ALDKETRDTASE.