UniProt Accession

 ELOC_MOUSE; P83940; Q63182 

Genbank Protein ID

 AK013089; AK011757; AK011958; AK012909; AK039746; BC009104; BC028545 

Genbank Nucleotide ID

 BAB28641.1; BAB27825.1; BAB27939.1; BAB28546.1; BAC30437.1; AAH09104.1; AAH28545.1 

Protein Name

 Transcription elongation factor B polypeptide 1 

Protein Synonyms/Alias

 Elongin 15 kDa subunit; Elongin-C; EloC; RNA polymerase II transcription factor SIII subunit C; SIII p15; Stromal membrane-associated protein SMAP1B homolog 

Gene Name

 Tceb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
32	DGHEFIVKREHALTS	acetylation	[1]
43	ALTSGTIKAMLSGPG	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 112 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030891; C:VCB complex; IEA:Compara.
 GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 

Interpro

 IPR011333; BTB/POZ_fold.
 IPR001232; Skp1_comp.
 IPR016073; Skp1_comp_POZ. 

Pfam

 PF03931; Skp1_POZ 

SMART

 SM00512; Skp1 

PROSITE

  

PRINTS