UniProt Accession

 RS13_HUMAN; P62277; B2R549; P19116; Q02546; Q29200; Q498Y0 

Genbank Protein ID

 L01124; X79239; D88010; AK312060; CH471064; BC000475; BC006772; BC029732; BC066322; BC100032; L05090 

Genbank Nucleotide ID

 AAA60283.1; CAA55821.1; BAA13528.1; BAG34996.1; EAW68448.1; AAH00475.1; AAH06772.1; AAH29732.1; AAH66322.1; AAI00033.1; AAC15854.1 

Protein Name

 40S ribosomal protein S13 

Protein Synonyms/Alias

  

Gene Name

 RPS13 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	GRMHAPGKGLSQSAL	ubiquitination	[1, 2, 3, 4]
27	RSVPTWLKLTSDDVK	acetylation	[5]
27	RSVPTWLKLTSDDVK	ubiquitination	[1, 3, 4, 6, 7]
34	KLTSDDVKEQIYKLA	ubiquitination	[2, 3, 6, 7]
39	DVKEQIYKLAKKGLT	acetylation	[5]
39	DVKEQIYKLAKKGLT	ubiquitination	[2, 3]
42	EQIYKLAKKGLTPSQ	ubiquitination	[2]
43	QIYKLAKKGLTPSQI	ubiquitination	[1, 2, 3, 4, 6, 7, 8, 9, 10]
70	VRFVTGNKILRILKS	ubiquitination	[1, 2, 3, 4, 7]
76	NKILRILKSKGLAPD	ubiquitination	[6]
78	ILRILKSKGLAPDLP	ubiquitination	[1, 2, 3, 4, 6, 7, 10]
93	EDLYHLIKKAVAVRK	acetylation	[5]
93	EDLYHLIKKAVAVRK	ubiquitination	[1, 3, 4, 6, 10]
94	DLYHLIKKAVAVRKH	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [8] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [9] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [10] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

 MOD_RES 27 27 N6-acetyllysine.
 MOD_RES 38 38 Phosphotyrosine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 151 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0003729; F:mRNA binding; IDA:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0033119; P:negative regulation of RNA splicing; IDA:UniProtKB.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR012606; Ribosomal_S13/S15_N.
 IPR000589; Ribosomal_S15.
 IPR023029; Ribosomal_S15P.
 IPR009068; S15_NS1_RNA-bd. 

Pfam

 PF08069; Ribosomal_S13_N
 PF00312; Ribosomal_S15 

SMART

  

PROSITE

 PS00362; RIBOSOMAL_S15 

PRINTS