UniProt Accession

 IDH1_YEAST; P28834; D6W1E2 

Genbank Protein ID

 M95203; Z71313; BK006947 

Genbank Nucleotide ID

 AAA34711.1; CAA95904.1; DAA10508.1 

Protein Name

 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial 

Protein Synonyms/Alias

 Isocitric dehydrogenase; NAD(+)-specific ICDH 

Gene Name

 IDH1 

Gene Synonyms/Alias

 YNL037C; N2690 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
41	IPGDGVGKEITDSVR	acetylation	[1]
71	NIKQTDHKEGVYEAV	acetylation	[1]
82	YEAVESLKRNKIGLK	acetylation	[1]
182	RFAFDFAKKYNRKSV	acetylation	[1]
199	VHKANIMKLGDGLFR	acetylation	[1]
324	EYATRISKAVHETIA	acetylation	[1]
334	HETIAEGKHTTRDIG	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'- untranslated leaders of mitochondrial mRNAs. 

Sequence Annotation

 METAL 228 228 Magnesium or manganese (By similarity).
 BINDING 109 109 Substrate (By similarity).
 BINDING 140 140 Substrate (By similarity).
 BINDING 228 228 Substrate (By similarity).  

Keyword

 3D-structure; Allosteric enzyme; Complete proteome; Direct protein sequencing; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Reference proteome; RNA-binding; Transit peptide; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome.
 GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IDA:SGD.
 GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
 GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006537; P:glutamate biosynthetic process; TAS:SGD.
 GO:0006102; P:isocitrate metabolic process; TAS:SGD.
 GO:0006099; P:tricarboxylic acid cycle; TAS:SGD. 

Interpro

 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR004434; Isocitrate_DH_NAD.
 IPR024084; IsoPropMal-DH-like_dom. 

Pfam

 PF00180; Iso_dh 

SMART

  

PROSITE

 PS00470; IDH_IMDH 

PRINTS