UniProt Accession

 PSMD8_MOUSE; Q9CX56 

Genbank Protein ID

 AC164564; AK020132 

Genbank Nucleotide ID

 BAB32006.2 

Protein Name

 26S proteasome non-ATPase regulatory subunit 8 

Protein Synonyms/Alias

 26S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14 

Gene Name

 Psmd8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
114	RKNPNLSKCGEELGR	ubiquitination	[1]
138	FLPTTGTKLTKQQLI	ubiquitination	[1]
141	TTGTKLTKQQLILAR	acetylation	[2]
141	TTGTKLTKQQLILAR	ubiquitination	[1]
284	CIEKAYEKILFAEAT	acetylation	[3]
300	ILFFSTPKKMTDYAK	ubiquitination	[1]
340	IPSTELAKQVIEYAR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0022624; C:proteasome accessory complex; IDA:UniProtKB.
 GO:0005838; C:proteasome regulatory particle; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 

Interpro

 IPR006746; 26S_Psome_Rpn12. 

Pfam

  

SMART

  

PROSITE

  

PRINTS