CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022314
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 161A 
Protein Synonyms/Alias
  
Gene Name
 TMEM161A 
Gene Synonyms/Alias
 UNQ582/PRO1152 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41NGSLFRYKHPSEEELubiquitination[1, 2]
54ELRALAGKPRPRGRKubiquitination[2, 3]
72ANGLSEEKPLSVPRDubiquitination[1, 2, 3, 4, 5]
213NLEPLLKKQGWDWALubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA LAGKPRPRGR 60
KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALVLRFF LEYQWFVDFA VYSGGVYLFT 120
EAYYYMLGPA KETNIAVFWC LLTVTFSIKM FLTVTRLYFS AEEGGERSVC LTFAFLFLLL 180
AMLVQVVREE TLELGLEPGL ASMTQNLEPL LKKQGWDWAL PVAKLAIRVG LAVVGSVLGA 240
FLTFPGLRLA QTHRDALTMS EDRPMLQFLL HTSFLSPLFI LWLWTKPIAR DFLHQPPFGE 300
TRFSLLSDSA FDSGRLWLLV VLCLLRLAVT RPHLQAYLCL AKARVEQLRR EAGRIEAREI 360
QQRVVRVYCY VTVVSLQYLT PLILTLNCTL LLKTLGGYSW GLGPAPLLSP DPSSASAAPI 420
GSGEDEVQQT AARIAGALGG LLTPLFLRGV LAYLIWWTAA CQLLASLFGL YFHQHLAGS 479 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0034599; P:cellular response to oxidative stress; IDA:BHF-UCL.
 GO:0034644; P:cellular response to UV; IDA:BHF-UCL.
 GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.
 GO:0045739; P:positive regulation of DNA repair; IMP:BHF-UCL.
 GO:0032526; P:response to retinoic acid; IDA:BHF-UCL. 
Interpro
 IPR019395; Transmembrane_161A/B. 
Pfam
 PF10268; Tmemb_161AB 
SMART
  
PROSITE
  
PRINTS