CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014983
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 425 
Protein Synonyms/Alias
  
Gene Name
 ZNF425 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
131LCAALRGKERKILLAacetylation[1]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 
Functional Description
 Acts as a transcriptional repressor. 
Sequence Annotation
 DOMAIN 9 80 KRAB.
 ZN_FING 190 212 C2H2-type 1.
 ZN_FING 246 268 C2H2-type 2.
 ZN_FING 274 296 C2H2-type 3.
 ZN_FING 302 324 C2H2-type 4.
 ZN_FING 330 352 C2H2-type 5.
 ZN_FING 358 380 C2H2-type 6.
 ZN_FING 386 408 C2H2-type 7.
 ZN_FING 414 436 C2H2-type 8.
 ZN_FING 442 464 C2H2-type 9.
 ZN_FING 470 492 C2H2-type 10.
 ZN_FING 498 520 C2H2-type 11.
 ZN_FING 526 548 C2H2-type 12.
 ZN_FING 554 576 C2H2-type 13.
 ZN_FING 582 604 C2H2-type 14.
 ZN_FING 610 632 C2H2-type 15.
 ZN_FING 638 660 C2H2-type 16.
 ZN_FING 666 688 C2H2-type 17.
 ZN_FING 694 716 C2H2-type 18.
 ZN_FING 722 744 C2H2-type 19.  
Keyword
 Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 752 AA 
Protein Sequence
MAEPASVTVT FDDVALYFSE QEWEILEKWQ KQMYKQEMKT NYETLDSLGY AFSKPDLITW 60
MEQGRMLLIS EQGCLDKTRR TTSPPTDEQL NMKNTGKLLC FDDEGTPRTK EEDCRLNGPQ 120
KQDLCAALRG KERKILLAQT ATFQSPSLRE TEILNKKVSI TAYDPDKKDL RHKPRETPGR 180
LEIPTGPRCY SCYVCRKVFQ VRRDLLKHKR SHSKSQLCRY PKYKNSSRGK SELRRTQRLL 240
CQKKRFQCSE CEKSYFLKGS LVTHQVVHTG QRPYPCPECD KTFRYRANLK KHLCLHRGER 300
PFCCGECGRA FVQQCELTEH LRLHSGEKPF QCPQCDRCFR LKRGMKVHLT QHSGKRPFHC 360
PECGRSFSRK AALKTHQRTH SEEKPFSCGE CGRKFIYKIK LDEHIRVHTG EKPFSCPECN 420
KSFRLKRSLK AHGLQHIGKR PFQCPECSRG FFWRNAMRAH QRLHSEQKPF PCAECGKRFT 480
RPSKLACHTR VHDRQKEFPC GECKKTFSQQ SRLTQHLKVH TTEKPFSCAE CGRSFRRRAH 540
LTEHTRLHSG EEPFQCPECD KSFSWKASMK FHQRMHRDEK PFACGECDKT YTHQSQLTEH 600
LRLHSGEKPY QCPECEKTFR LKGNLKSHLL QHSGQKPFSC VMCGKSFTQQ YRLTEHIRVH 660
SGEKPFQCPE CDKSYCIRGS LKVHLYKHSG ERPFQCPECG KGFLQKRSLK AHLCLHSGER 720
PFSCDECGRS FTYVGALKTH IAVHAKEKPS SL 752 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS