| Tag | Content |
|---|
| CPLM ID | CPLM-010155 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UvrABC system protein B |
Protein Synonyms/Alias | Protein UvrB; Excinuclease ABC subunit B |
Gene Name | uvrB |
Gene Synonyms/Alias | MPN_211; MP620 |
Created Date | July 27, 2013 |
Organism | Mycoplasma pneumoniae (strain ATCC 29342 / M129) |
NCBI Taxa ID | 272634 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 9 | KSPTKDSKLFHLKSN | acetylation | [1] | | 275 | AELKDRLKYFERLNF | acetylation | [1] |
|
Reference | [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC. Mol Syst Biol. 2012 Feb 28;8:571. [ PMID: 22373819] |
Functional Description | The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity). |
Sequence Annotation | DOMAIN 29 416 Helicase ATP-binding.
DOMAIN 435 597 Helicase C-terminal.
DOMAIN 615 650 UVR.
NP_BIND 42 49 ATP (Potential).
MOTIF 95 118 Beta-hairpin. |
Keyword | ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome; SOS response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 657 AA |
Protein Sequence | MKSPTKDSKL FHLKSNFAPT GDQPAAIAKL AEFQTNEQVL LGATGTGKTF TIANVIQKVQ 60
LPTVVIAHNK TLAGQLYQEL KELFPNNAVE YFISYFDFYQ PEAYLPAKGV YIEKSATVNE 120
EIKRLRVSTL HSLSTRKDVI VVGSVASIYP TSSPADFAQY SLWLVVGKEY GLSELKTQLI 180
HLNYVVNKQQ LTPGKFRFQG DVVEVFPGYA QDYVLRLSFF DQQLEQIARI DPLTNKVLET 240
LNSFKLGPAD EYIVNQNDLG VALDTIKAEL KDRLKYFERL NFPERAQRLQ TITEHDLADL 300
KAWGVCSGVE NYARHLEHRP PHSKPYNIFD YFTKGEWLLV VDESHQTLPQ IKGMYNTDIS 360
RKQSLIEYGF RLPSALDNRP LSYEEFRQGI NKVIYVSATP REEEIQLSHN NVVEQLVRPT 420
YLLDPEVIVK PKDNQVEDLV SEIINQRKHN GRTFVTVLTI KMAENLTDFL KERNIKVAYI 480
HKDIKALERL ILLTDLRKGE YECLVGINLL REGLDVPEVS LVAIFDADIP GLPRDERSLI 540
QIIGRAARNV HGRVIMYANT ISEQMDKAIK ETQRRRTIQM AYNEQHHKTP MTVQKPITLN 600
QPIKLKTKSS EQQKAALIKQ LTKEMKQAAA NQNYELAIEI RDSIFELEKQ FRGKIKS 657 |
Gene Ontology | |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |