| Tag | Content |
|---|
| CPLM ID | CPLM-011399 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pre-mRNA-splicing factor SPP382 |
Protein Synonyms/Alias | CLF1 complex factor 8; Nineteen complex-related protein 1; NTC-related protein 1; Suppressor of PRP38 protein 2 |
Gene Name | SPP382 |
Gene Synonyms/Alias | CCF8; NTR1; YLR424W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 57 | GNAPTISKLTKTYGI | acetylation | [1] | | 78 | SMGYVAGKGLGKDGS | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex. |
Sequence Annotation | DOMAIN 61 108 G-patch. |
Keyword | Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 708 AA |
Protein Sequence | MEDSDSNTDK KFFFKKRRID SYNYSDEEDN NSSMNSDMTY TNDALKTSSG NAPTISKLTK 60
TYGIGAKLLS SMGYVAGKGL GKDGSGITTP IETQSRPMHN AGLGMFSNTN SSNYHSENED 120
YLSSEDEVVE GIEQVKFNKT STEVLGEALL NDSGDMTIVR TLRELRLAGV QLPESILKEL 180
DPLNAVPKPK KDVVVEILQE LLGIEKSLEA IRQRTSPLEV QVKEYYGQER LLSELEVTLR 240
DESKHVSLYD KIGAILKLSD DELIDRLTSC LLRKELLIEF DLDHLEKPND ILDELTQIIE 300
LLAYRMDTTS KFLNRTQTTI FKVIYPKLKK FWEGFDMTKS KIDSAITLLL DFQQVLSFIG 360
CKEHIMEEFV YPKLLQELDN WELHDEVDHV SPRIWVLDFM VLIDDKIKDT IVDKIEAKFF 420
AYCKNWYHRE SFCITNSDII FIKELICERR YYKILCKEFL PKFLDELWER HNDPIYELED 480
WKEKQEWKEK DSGFFYFMKK LRSYTHYFHP KQYELMMRGT FNNINKILYQ WHLYSTVEDL 540
HKSKWWLNWL MNTVFEHSLP TEIELSEIRK SYNIFAMSHR YHLDKSTLDE DFDLRQGLRN 600
LMETQVIDDI SQSEQEPTYT VQNIPLGKVS SSFKDVVEDY CLEKGYLISK IPNRYTQLPY 660
GRDQDCIVPL FEIRNGKKKM EVALKHDILW VEDSSGTFKP IYLWALDL 708 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IDA:SGD. GO:0003723; F:RNA binding; ISS:SGD. GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IMP:SGD. GO:0000390; P:spliceosomal complex disassembly; IDA:SGD. |
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Pfam | |
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