| Tag | Content |
|---|
| CPLM ID | CPLM-004953 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pre-mRNA-splicing factor ISY1 |
Protein Synonyms/Alias | Interactor of SYF1; PRP19-associated complex protein 30 |
Gene Name | ISY1 |
Gene Synonyms/Alias | NTC30; UTR3; YJR050W; J1657 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 7 | *MSRNVDKANSVLVR | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in pre-mRNA splicing and cell cycle control. As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. The cell cycle arrest of SYF2 defective cells may be due to the inefficient splicing of TUB1. Also involved in DNA repair. |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 235 AA |
Protein Sequence | MSRNVDKANS VLVRFQEQQA ESAGGYKDYS RYQRPRNVSK VKSIKEANEW KRQVSKEIKQ 60
KSTRIYDPSL NEMQIAELND ELNNLFKEWK RWQWHIDHTL MEKKTKRKRL EDSHVLMNSG 120
KLINGKRYFG RALELPEVKE WLKQSQRQND GGSINTKCIP KDRNDFYYHG KVTAALTEFE 180
ANWTSILKAH YNVPVNEDEE EMSRQTQEIH VPTLADMEHW LVQRRKKKLM DELNL 235 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0071014; C:post-mRNA release spliceosomal complex; IDA:SGD. GO:0071020; C:post-spliceosomal complex; IDA:SGD. GO:0000974; C:Prp19 complex; IDA:SGD. GO:0071006; C:U2-type catalytic step 1 spliceosome; IDA:SGD. GO:0071007; C:U2-type catalytic step 2 spliceosome; IDA:SGD. GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IMP:SGD. GO:0000389; P:mRNA 3'-splice site recognition; IMP:SGD. |
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PRINTS | |