CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022982
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dimethylglycine dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 ME2GLYDH 
Gene Name
 DMGDH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37CGREGEEKPPLSAETacetylation[1]
118DSIKLYEKLEEETGQacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 MOD_RES 91 91 Tele-8alpha-FAD histidine (By  
Keyword
 Complete proteome; Disease mutation; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 866 AA 
Protein Sequence
MLRPGAQLLR GLLLRSCPLQ GSPGRPRSVC GREGEEKPPL SAETQWKDRA ETVIIGGGCV 60
GVSLAYHLAK AGMKDVVLLE KSELTAGSTW HAAGLTTYFH PGINLKKIHY DSIKLYEKLE 120
EETGQVVGFH QPGSIRLATT PVRVDEFKYQ MTRTGWHATE QYLIEPEKIQ EMFPLLNMNK 180
VLAGLYNPGD GHIDPYSLTM ALAAGARKCG ALLKYPAPVT SLKARSDGTW DVETPQGSMR 240
ANRIVNAAGF WAREVGKMIG LEHPLIPVQH QYVVTSTISE VKALKRELPV LRDLEGSYYL 300
RQERDGLLFG PYESQEKMKV QDSWVTNGVP PGFGKELFES DLDRIMEHIK AAMEMVPVLK 360
KADIINVVNG PITYSPDILP MVGPHQGVRN YWVAIGFGYG IIHAGGVGKY LSDWILHGEP 420
PFDLIELDPN RYGKWTTTQY TEAKARESYG FNNIVGYPKE ERFAGRPTQR VSGLYQRLES 480
KCSMGFHAGW EQPHWFYKPG QDTQYRPSFR RTNWFEPVGS EYKQVMQRVA VTDLSPFGKF 540
NIKGQDSIRL LDHLFANVIP KVGFTNISHM LTPKGRVYAE LTVSHQSPGE FLLITGSGSE 600
LHDLRWIEEE AVKGGYDVEI KNITDELGVL GVAGPQARKV LQKLTSEDLS DDVFKFLQTK 660
SLKVSNIPVT AIRISYTGEL GWELYHRRED SVALYDAIMN AGQEEGIDNF GTYAMNALRL 720
EKAFRAWGLE MNCDTNPLEA GLEYFVKLNK PADFIGKQAL KQIKAKGLKR RLVCLTLATD 780
DVDPEGNESI WYNGKVVGNT TSGSYSYSIQ KSLAFAYVPV QLSEVGQQVE VELLGKNYPA 840
VIIQEPLVLT EPTRNRLQKK GGKDKT 866 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; NAS:UniProtKB.
 GO:0004047; F:aminomethyltransferase activity; IEA:InterPro.
 GO:0047865; F:dimethylglycine dehydrogenase activity; IMP:UniProtKB.
 GO:0009055; F:electron carrier activity; NAS:UniProtKB.
 GO:0006579; P:amino-acid betaine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0019695; P:choline metabolic process; NAS:UniProtKB.
 GO:0006546; P:glycine catabolic process; IEA:InterPro.
 GO:0006544; P:glycine metabolic process; IMP:UniProtKB. 
Interpro
 IPR006076; FAD-dep_OxRdtase.
 IPR013977; GCV_T_C.
 IPR006222; GCV_T_N.
 IPR027266; TrmE/GcvT_dom1. 
Pfam
 PF01266; DAO
 PF01571; GCV_T
 PF08669; GCV_T_C 
SMART
  
PROSITE
  
PRINTS