CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005657
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gap junction alpha-4 protein 
Protein Synonyms/Alias
 Connexin-37; Cx37 
Gene Name
 Gja4 
Gene Synonyms/Alias
 Cxn-37 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
119ELRALPSKDLHVERAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Gap junction; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 333 AA 
Protein Sequence
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG 60
CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS RREERLRQKE GELRALPSKD 120
LHVERALAAI EHQMAKISVA EDGRLRIRGA LMGTYVVSVL CKSVLEAGFL YGQWRLYGWT 180
MEPVFVCQRA PCPHIVDCYV SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI 240
KARRDHDARP AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL 300
TSSRPPPFVN TAPQGGRKSP SRPNSSASKK QYV 333 
Gene Ontology
 GO:0005922; C:connexon complex; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0001568; P:blood vessel development; IMP:MGI.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0007267; P:cell-cell signaling; IEA:Compara.
 GO:0048265; P:response to pain; IEA:Compara. 
Interpro
 IPR000500; Connexin.
 IPR002263; Connexin37.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 
Pfam
 PF00029; Connexin
 PF10582; Connexin_CCC 
SMART
 SM00037; CNX
 SM01089; Connexin_CCC 
PROSITE
 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 
PRINTS
 PR00206; CONNEXIN.
 PR01134; CONNEXINA4.