CPLM-007537

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-007537

UniProt Accession

ECI1_HUMAN; P42126; A8K512; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6

Genbank Protein ID

Z25820; Z25821; Z25822; Z25823; Z25824; AK291127; CH471112; BC000762; BC002746; BC020228; BC019316; L24774

Genbank Nucleotide ID

CAA81065.1; CAA81066.1; CAA81066.1; CAA81066.1; CAA81066.1; BAF83816.1; EAW85524.1; AAH00762.1; AAH02746.1; AAH20228.1; AAH19316.1; AAA35485.1

Protein Name

Enoyl-CoA delta isomerase 1, mitochondrial

Protein Synonyms/Alias

3,2-trans-enoyl-CoA isomerase; Delta(3),Delta(2)-enoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase

Gene Name

ECI1

Gene Synonyms/Alias

DCI

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
61	GAGVAVMKFKNPPVN	ubiquitination	[1]
266	NFVSFISKDSIQKSL	ubiquitination	[1]
271	ISKDSIQKSLQMYLE	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.

Sequence Annotation

REGION 106 110 Substrate binding.
BINDING 153 153 Substrate; via amide nitrogen.
BINDING 177 177 Substrate.
MOD_RES 89 89 N6-acetyllysine.

Keyword

3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Fatty acid metabolism; Isomerase; Lipid metabolism; Mitochondrion; Reference proteome; Transit peptide.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

302 AA

Protein Sequence

MALVASVRVP ARVLLRAGAR LPGAALGRTE RAAGGGDGAR RFGSQRVLVE PDAGAGVAVM 60
KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR PGVFSAGLDL TEMCGRSPAH 120
YAGYWKAVQE LWLRLYQSNL VLVSAINGAC PAGGCLVALT CDYRILADNP RLKDTLENTI 180
GHRAAERALQ LGLLFPPAEA LQVGIVDQVV PEEQVQSTAL SAIAQWMAIP DHARQLTKAM 240
MRKATASRLV TQRDADVQNF VSFISKDSIQ KSLQMYLERL KEEKG 285

Gene Ontology

GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
GO:0005759; C:mitochondrial matrix; NAS:UniProtKB.
GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; NAS:UniProtKB.
GO:0006635; P:fatty acid beta-oxidation; NAS:UniProtKB.

Interpro

IPR001753; Crotonase_core_superfam.
IPR018376; Enoyl-CoA_hyd/isom_CS.

Pfam

PF00378; ECH

SMART

PROSITE

PS00166; ENOYL_COA_HYDRATASE

PRINTS