Tag | Content |
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CPLM ID | CPLM-041079 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-lysine N-methyltransferase MLL4 |
Protein Synonyms/Alias | |
Gene Name | Kmt2b |
Gene Synonyms/Alias | Wbp7 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1698 | HTDLLDGKEIVTPDG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | |
Keyword | Complete proteome; Metal-binding; Methyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2721 AA |
Protein Sequence | MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGNGA ERVRVALRRG GGAAGPGGAE 60 PGEDTALLRL LGLRRGLRRL RRLWAGARVQ RGRGRGRGRG WGPNRGCMPE EESSDGESEE 120 EEFQGFHSDE DVAPSSLRSA LRSQRGRAPR GRGRKHKTTP LPPRLADVTP VPPKAPTRKR 180 GEEGTERMVQ ALTELLRRSQ APQPPRSRAR AREPSTPRRS RGRPPGRPAG PCRKKQQAVV 240 LAEAAVTIPK PEPPPPVVPV KNKAGSWKCK EGPGPGPGTP KRGGQPGRGG RGGRGRGRGG 300 LPLMIKFVSK AKKVKMGQLS QELESGQGHG QRGESWQDAP QRKDGDEPER GSCRKKQEQK 360 LEEEEEEEEK EGEEKEEKDD NEDNNKQEEE EETERAVAEE EAMLAKEKEE AKLPSPPLTP 420 PVPSPPPPLP PPSTSPPPPA SPLPPPVSPP PPLSPPPYPA PEKQEESPPL VPATCSRKRG 480 RPPLTPSQRA EREAARSGPE GTLSPTPNPS TTTGSPLEDS PTVVPKSTTF LKNIRQFIMP 540 VVSARSSRVI KTPRRFMDED PPKPPKVEAS IVRPPVATSP PAPQEPVPVS SPPRVPTPPS 600 TPVPLPEKRR SILREPTFRW TSLTRELPPP PPAPPPAPSP PPAPATPSRR PLLLRAPQFT 660 PSEAHLKIYE SVLTPPPLGA LETPEPELPP ADDSPAEPEP RAVGRTNHLS LPRFVPVVTS 720 PVKVEVPPHG APALSEGQQL QLQQPPQALQ TQLLPQALPP QQPQAQPPPS PQHTPPLEKA 780 RVASLGSLPL SGVEEKMFSL LKRAKVQLFK IDQQQQQKVA ASMPLSPAVQ TEEAVGTVKQ 840 TPDRGCVRSE DESMEAKRDR ASGPESPLQG PRIKHVCRHA AVALGQARAM VPEDVPRLSA 900 LPLRDRQDLA TEDTSSASET ESVPSRSQRE KVESAGPGGD SEPTGSTGAL AHTPRRSLPS 960 HHGKKMRMAR CGHCRGCLRV QDCGSCVNCL DKPKFGGPNT KKQCCVYRKC DKIEARKMER 1020 LAKKGRTIVK TLLPWDSDES PEASPGPPGP RRGAGAGGSR EEVGATPGPE EQDSLLLQRK 1080 SARRCVKQRP SYDVFEDSDD SEPGGPPAPR RRTPREHELP VLEPEEQSRP RKPTLQPVLQ 1140 LKARRRLDKD ALAPGPFASF PNGWTGKQKS PDGVHRVRVD FKEDCDLENV WLMGGLSVLT 1200 SVPGGPPMVC LLCASKGLHE LVFCQVCCDP FHPFCLEEAE RPSPQHRDTW CCRRCKFCHV 1260 CGRKGRGSKH LLECERCRHA YHPACLGPSY PTRATRRRRH WICSACVRCK SCGATPGKNW 1320 DVEWSGDYSL CPRCTELYEK GNYCPICTRC YEDNDYESKM MQCAQCDHWV HAKCEGLSDE 1380 DYEILSGLPD SVLYTCGPCA GATQPRWREA LSGALQGGLR QVLQGLLSSK VAGPLLLCTQ 1440 CGQDGKQLHP GPCDLQAVGK RFEEGLYKSV HSFMEDVVAI LMRHSEEGET PERRAGSQMK 1500 GLLLKLLESA FCWFDAHDPK YWRRSTRLPN GVLPNAVLPP SLDHVYAQWR QQESETPESG 1560 QPPGDPSAAF QSKDPAAFSH LDDPRQCALC LKYGDADSKE AGRLLYIGQN EWTHVNCAIW 1620 SAEVFEENDG SLKNVHAAVA RGRQMRCELC LKPGATVGCC LSSCLSNFHF MCARASYCIF 1680 QDDKKVFCQK HTDLLDGKEI VTPDGFDVLR RVYVDFEGIN FKRKFLTGLE PDVINVLIGS 1740 IRINSLGTLS DLSDCEGRLF PIGYQCSRLY WSTVDARRRC WYRCRILEYR PWGPREEPVH 1800 LEAAEENQTI VHSPTPSSEP PNHDDLPDTD SLIPGDPVHH SPIQNLDPPL RTDSSNGPPP 1860 TPRSFSGARI KVPNYSPSRR PLGGVSFGPL PSPGSPSSLT HHIPTVGDSD FPAPPRRSRR 1920 PSPLATRPPP SRRTSSPLRT SPQLRVPLST SVTALTPTSG ELAPPDLAPS PLPPSEDLGP 1980 DFEDMEVVSG LSAADLDFAA SLLGTEPFQE EIVAAGAVGS SQGGPGDSSE EEASPTTHYV 2040 HFPVTVVSGP ALAPSSLAGA PRIEQLDGVD DGTDSEAEAV QQPRGQGTPP SGPGVGRGGV 2100 LGAAGDRAQP PEDLPSEIVD FVLKNLGGPG EGAAGPREDS LPSAPPLANG SQPPQSLSTS 2160 PADPTRTFAW LPGAPGVRVL SLGPAPEPPK PATSKIILVN KLGQVFVKMA GEGEPVAPPV 2220 KQPPLPPIIP PTAPTSWTLP PGPLLSVLPV VGVGVVRPAP PPPPPPLTLV FSSGPPSPPR 2280 QAIRVKRVST FSGRSPPVPP PNKTPRLDED GESLEDAHHV PGISGSGFSR VRMKTPTVRG 2340 VLDLNNPGEQ PEEESPGRPQ DRCPLLPLAE APSQALDGSS DLLFESQWHH YSGEASSSEE 2400 EPPSPEDKEN QVPKRVGPHL RFEISSDDGF SVEAESLEVA WRTLIEKVQE ARGHARLRHL 2460 SFSGMSGARL LGIHHDAVIF LAEQLPGAQR CQHYKFRYHQ QGEGQEEPPL NPHGAARAEV 2520 YLRKCTFDMF NFLASQHRVL PEGATCDEEE DEVQLRSTRR ATSLELPMAM RFRHLKKTSK 2580 EAVGVYRSAI HGRGLFCKRN IDAGEMVIEY SGIVIRSVLT DKREKFYDGK GIGCYMFRMD 2640 DFDVVDATMH GNAARFINHS CEPNCFSRVI HVEGQKHIVI FALRRILRGE ELTYDYKFPI 2700 EDASNKLPCN CGAKRCRRFL N 2721 |
Gene Ontology | GO:0035097; C:histone methyltransferase complex; ISO:MGI. GO:0003677; F:DNA binding; IEA:InterPro. GO:0042800; F:histone methyltransferase activity (H3-K4 specific); ISO:MGI. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016458; P:gene silencing; IMP:MGI. GO:0080182; P:histone H3-K4 trimethylation; IMP:MGI. GO:0009994; P:oocyte differentiation; IMP:MGI. GO:0001541; P:ovarian follicle development; IMP:MGI. GO:0030728; P:ovulation; IMP:MGI. GO:0051569; P:regulation of histone H3-K4 methylation; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |