CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008449
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neutral amino acid transporter B(0) 
Protein Synonyms/Alias
 ATB(0); ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Insulin-activated amino acid transporter; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 
Gene Name
 Slc1a5 
Gene Synonyms/Alias
 Aaat; Asct2; Slc1a7 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
502QSYVDRTKMPSSEPEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Insulin-dependent transporter for L-serine and, to a lesser extent, uptake of L-alanine and L-glutamate. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 505 505 Phosphoserine (By similarity).
 CARBOHYD 165 165 N-linked (GlcNAc...) (Potential).
 CARBOHYD 228 228 N-linked (GlcNAc...) (Potential).  
Keyword
 Acetylation; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 553 AA 
Protein Sequence
MAVDPPKADP KGVAVDSSRR CPALGSREDQ SAKAGGCCGS RDRVRRCIRA NLLVLLTVAA 60
VVAGVGLGLG VSAAGGADAL GPARLTRFAF PGELLLRLLK MIILPLVVCS LIGGAASLDP 120
SALGRVGAWA LLFFLVTTLL ASALGVGLAL ALKPGAAVTA ITSINDSVVD PCARSAPTKE 180
ALDSFLDLVR NIFPSNLVSA AFRSFATSYE PKDNSCKIPQ SCIQREINST MVQLLCEVEG 240
MNILGLVVFA IVFGVALRKL GPEGELLIRF FNSFNDATMV LVSWIMWYAP VGILFLVASK 300
IVEMKDVRQL FISLGKYILC CLLGHAIHGL LVLPLIYFLF TRKNPYRFLW GIMTPLATAF 360
GTSSSSATLP LMMKCVEEKN GVAKHISRFI LPIGATVNMD GAALFQCVAA VFIAQLNGVS 420
LDFVKIITIL VTATASSVGA AGIPAGGVLT LAIILEAVSL PVKDISLILA VDWLVDRSCT 480
VLNVEGDAFG AGLLQSYVDR TKMPSSEPEL IQVKNEVSLN PLPLATEEGN PLLKQYQGPT 540
GDSSATFEKE SVM 553 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0015175; F:neutral amino acid transmembrane transporter activity; IDA:MGI.
 GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro. 
Interpro
 IPR001991; Na-dicarboxylate_symporter.
 IPR018107; Na-dicarboxylate_symporter_CS. 
Pfam
 PF00375; SDF 
SMART
  
PROSITE
 PS00713; NA_DICARBOXYL_SYMP_1
 PS00714; NA_DICARBOXYL_SYMP_2 
PRINTS
 PR00173; EDTRNSPORT.