UniProt Accession

 F6X9I3_MOUSE; F6X9I3 

Genbank Protein ID

 AL928719 

Genbank Nucleotide ID

  

Protein Name

 Peptidyl-prolyl cis-trans isomerase 

Protein Synonyms/Alias

  

Gene Name

 Fkbp1a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
98	DSSRDRNKPFKFTLG	acetylation	[1]
101	RDRNKPFKFTLGKQE	acetylation	[1]
101	RDRNKPFKFTLGKQE	ubiquitination	[2]
106	PFKFTLGKQEVIRGW	acetylation	[1, 3, 4]
106	PFKFTLGKQEVIRGW	succinylation	[4]
106	PFKFTLGKQEVIRGW	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Isomerase; Reference proteome; Rotamase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IBA:RefGenome.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0033017; C:sarcoplasmic reticulum membrane; IDA:MGI.
 GO:0005528; F:FK506 binding; IDA:MGI.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0019221; P:cytokine-mediated signaling pathway; IMP:MGI.
 GO:0006936; P:muscle contraction; IMP:MGI.
 GO:0032513; P:negative regulation of protein phosphatase type 2B activity; IBA:RefGenome.
 GO:0001933; P:negative regulation of protein phosphorylation; IDA:MGI.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:MGI.
 GO:0031000; P:response to caffeine; IMP:MGI.
 GO:0042098; P:T cell proliferation; IMP:MGI. 

Interpro

 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE 

PRINTS