| Tag | Content |
|---|
| CPLM ID | CPLM-000352 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RIMS-binding protein 2 |
Protein Synonyms/Alias | RIM-BP2 |
Gene Name | RIMBP2 |
Gene Synonyms/Alias | KIAA0318; RBP2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 727 | ASVDDFLKGSELGKQ | ubiquitination | [1, 2] | | 733 | LKGSELGKQPHCCHG | ubiquitination | [1, 2] |
|
Reference | [1] Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D. Proteomics. 2007 Mar;7(6):868-74. [ PMID: 17370265] [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B (By similarity). |
Sequence Annotation | DOMAIN 167 234 SH3 1.
DOMAIN 297 377 Fibronectin type-III 1.
DOMAIN 391 463 Fibronectin type-III 2.
DOMAIN 487 573 Fibronectin type-III 3.
DOMAIN 848 916 SH3 2.
DOMAIN 952 1019 SH3 3.
MOD_RES 832 832 Phosphoserine (By similarity).
CROSSLNK 727 727 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 733 733 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Isopeptide bond; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain; Synapse; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1052 AA |
Protein Sequence | MREAAERRQQ LQLEHDQALA VLSAKQQEID LLQKSKVREL EEKCRTQSEQ FNLLSRDLEK 60
FRQHAGKIDL LGGSAVAPLD ISTAPSKPFP QFMNGLATSL GKGQESAIGG SSAIGEYIRP 120
LPQPGDRPEP LSAKPTFLSR SGSARCRSES DMENERNSNT SKQRYSGKVH LCVARYSYNP 180
FDGPNENPEA ELPLTAGKYL YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRLA 240
STLGNEQDQN FINHSGIGLE GEHILDLHSP THIDAGITDN SAGTLDVNID DIGEDIVPYP 300
RKITLIKQLA KSVIVGWEPP AVPPGWGTVS SYNVLVDKET RMNLTLGSRT KALIEKLNMA 360
ACTYRISVQC VTSRGSSDEL QCTLLVGKDV VVAPSHLRVD NITQISAQLS WLPTNSNYSH 420
VIFLNEEEFD IVKAARYKYQ FFNLRPNMAY KVKVLAKPHQ MPWQLPLEQR EKKEAFVEFS 480
TLPAGPPAPP QDVTVQAGVT PATIRVSWRP PVLTPTGLSN GANVTGYGVY AKGQRVAEVI 540
FPTADSTAVE LVRLRSLEAK GVTVRTLSAQ GESVDSAVAA VPPELLVPPT PHPRPAPQSK 600
PLASSGVPET KDEHLGPHAR MDEAWEQSRA PGPVHGHMLE PPVGPGRRSP SPSRILPQPQ 660
GTPVSTTVAK AMAREAAQRV AESSRLEKRS VFLERSSAGQ YAASDEEDAY DSPDFKRRGA 720
SVDDFLKGSE LGKQPHCCHG DEYHTESSRG SDLSDIMEED EEELYSEMQL EDGGRRRPSG 780
TSHNALKILG NPASAGRVDH MGRRFPRGSA GPQRSRPVTV PSIDDYGRDR LSPDFYEESE 840
TDPGAEELPA RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC 900
ARLGLIPCNM VSEIQADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRRH SVSTRRMVAL 960
YDYDPRESSP NVDVEAELTF CTGDIITVFG EIDEDGFYYG ELNGQKGLVP SNFLEEVPDD 1020
VEVYLSDAPS HYSQDTPMRS KAKRKKSVHF TP 1052 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0045202; C:synapse; IEA:UniProtKB-SubCell. GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |