UniProt Accession

 NOP10_YEAST; Q6Q547; D3DL22 

Genbank Protein ID

 U10556; AY558548; BK006934 

Genbank Nucleotide ID

 AAS56874.1; DAA06766.1 

Protein Name

 H/ACA ribonucleoprotein complex subunit 3 

Protein Synonyms/Alias

 Nucleolar protein 10; Nucleolar protein family A member 3; snoRNP protein NOP10 

Gene Name

 NOP10 

Gene Synonyms/Alias

 YHR072W-A 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
28	TESGEITKSAHPARF	ubiquitination	[1, 2]
40	ARFSPDDKYSRQRVT	acetylation	[3]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. Essential for growth. 

Sequence Annotation

 MOD_RES 36 36 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 58 AA 

Protein Sequence

Gene Ontology

 GO:0031429; C:box H/ACA snoRNP complex; IPI:SGD.
 GO:0003723; F:RNA binding; IDA:SGD.
 GO:0000469; P:cleavage involved in rRNA processing; IMP:SGD.
 GO:0031118; P:rRNA pseudouridine synthesis; IMP:SGD.
 GO:0031120; P:snRNA pseudouridine synthesis; IDA:SGD. 

Interpro

 IPR007264; H/ACA_rnp_Nop10. 

Pfam

 PF04135; Nop10p 

SMART

  

PROSITE

  

PRINTS