CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013818
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcyclin-binding protein 
Protein Synonyms/Alias
 CacyBP 
Gene Name
 CACYBP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 
NCBI Taxa ID
 9601 
Lysine Modification
Position
Peptide
Type
References
85YGWDQSDKFVKIYITubiquitination[1, 2]
118RSFDLLVKNLNGKSYubiquitination[1, 2]
123LVKNLNGKSYSMIVNubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). 
Sequence Annotation
 DOMAIN 73 167 CS.
 DOMAIN 168 228 SGS.
 REGION 2 80 Interaction with SIAH1 (By similarity).
 REGION 73 228 Interaction with SKP1 (By similarity).
 REGION 154 228 Interaction with S100A6 (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 19 19 N6-acetyllysine (By similarity).
 MOD_RES 85 85 N6-acetyllysine (By similarity).
 MOD_RES 118 118 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 228 AA 
Protein Sequence
MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK KAELLDNEKP 60
AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP TENVQVHFTE RSFDLLVKNL 120
NGKSYSMIVN NLLKPISVEG SSKKVKTDTV LILCRKKVEN TRWDYLTQVE KERKEKEKPS 180
YDAETDPSEG LMNVLKKIYE DGDDDMKRTI NKAWVESREK QAKGDTEF 228 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone.
 IPR007699; SGS.
 IPR015120; Siah-Interact_N. 
Pfam
 PF04969; CS
 PF05002; SGS
 PF09032; Siah-Interact_N 
SMART
  
PROSITE
 PS51203; CS
 PS51048; SGS 
PRINTS