| Tag | Content |
|---|
| CPLM ID | CPLM-007340 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pre-B-cell leukemia transcription factor 2 |
Protein Synonyms/Alias | Homeobox protein PBX2; Protein G17 |
Gene Name | PBX2 |
Gene Synonyms/Alias | G17 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 308 | RYKKNIGKFQEEANI | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. |
Sequence Annotation | DNA_BIND 244 306 Homeobox; TALE-type.
MOD_RES 151 151 Phosphoserine.
MOD_RES 330 330 Phosphoserine. |
Keyword | Activator; Complete proteome; DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 430 AA |
Protein Sequence | MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK QDIGDILQQI 60
MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL SIRSSQEEEP VDPQLMRLDN 120
MLLAEGVAGP EKGGGSAAAA AAAAASGGGV SPDNSIEHSD YRSKLAQIRH IYHSELEKYE 180
QACNEFTTHV MNLLREQSRT RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR 240
FLDARRKRRN FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI 300
RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS GSGDMFLGMP 360
GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR ANGSWQEAVT PSSVTSPTEG 420
PGSVHSDTSN 430 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0005667; C:transcription factor complex; IEA:Compara. GO:0003682; F:chromatin binding; IEA:Compara. GO:0043565; F:sequence-specific DNA binding; IEA:Compara. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara. GO:0030326; P:embryonic limb morphogenesis; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0009954; P:proximal/distal pattern formation; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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