CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038707
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Solute carrier family 12 member 2 
Protein Synonyms/Alias
  
Gene Name
 Slc12a2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
246ELHDELEKEPFEDGFubiquitination[1]
274VAYTAESKGVVKFGWubiquitination[1]
625KIFQALCKDNIYPAFubiquitination[1]
827GPRRQAMKEMSIDQAubiquitination[1]
937ELLSSQEKSPGTKDVubiquitination[1]
942QEKSPGTKDVVVNVDubiquitination[1]
985TPTQPLLKKESKGPIubiquitination[1]
989PLLKKESKGPIVPLNubiquitination[1]
1001PLNVADQKLLEASTQubiquitination[1]
1011EASTQFQKKQGKNTIubiquitination[1]
1055IRVFIGGKINRIDHDubiquitination[1]
1072AMATLLSKFRIDFSDubiquitination[1]
1089VLGDINTKPKKENIIubiquitination[1]
1092DINTKPKKENIIAFDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1206 AA 
Protein Sequence
MEPGPAAPSS GAPRPARDGD APLAAAAGVD LPGTAVPSGQ EDATTAGRQA GGGVRGEGTP 60
AAGDGLGRPL GPTPSQSRFQ VDPVSENAGR AAAAAAAAAA AAAAAGAAGK ETPAAGKAGG 120
ESGVAKGSEE AKGRFRVNFV DPAASSSADD SLSDAAGVGG DGPNVSFQNG GDTVLSEGSS 180
LHSGGGSGHH QQYYYDTHTN TYYLRTFGHN TMDAVPRIDH YRHTAAQLGE KLLRPSLAEL 240
HDELEKEPFE DGFANGEEST PTRDAVVAYT AESKGVVKFG WIKGVLVRCM LNIWGVMLFI 300
RLSWIVGQAG IGLSVVVIAM ATVVTTITGL STSAIATNGF VRGGGAYYLI SRSLGPEFGG 360
AIGLIFAFAN AVAVAMYVVG FAETVVELLK EHSILMIDEI NDIRIIGAIT VVILLGISVA 420
GMEWEAKAQI VLLVILLLAI ADFVIGTFIS LESKKPKGFF GYKSEIFNEN FGPDFREEET 480
FFSVFAIFFP AATGILAGAN ISGDLADPQS AIPKGTLLAI LITTVVYIGI AVSVGSCVVR 540
DATGNVNDTI TTELTNCTSA ACKLNFDFSY CESNTCSYGL MNNFQVMSMV SGFAPLISAG 600
IFSATLSSAL ASLVSAPKIF QALCKDNIYP AFQMFAKGYG KNNEPLRGYI LTFLIALGFI 660
LIAELNVIAP IISNFFLASY ALINFSVFHA SLAKSPGWRP AFKYYNMWIS LIGAILCCIV 720
MFVINWWAAL LTYVIVLGLY IYVTYKKPDV NWGSSTQALT YLSALQHSIR LSGVEDHVKN 780
FRPQCLVMTG SPNSRPALLH LVHDFTKNVG LMICGHVHMG PRRQAMKEMS IDQARYQRWL 840
IKNKMKAFYA PVHADDLREG AQYLMQAAGL GRMKPNTLVL GFKKDWLQAD MRDVDMYINL 900
FHDAFDIQFG VVVIRLKEGL DISHLQGQEE LLSSQEKSPG TKDVVVNVDY SKKSDQDTCK 960
SSGEKSITQK DEEEDGKTPT QPLLKKESKG PIVPLNVADQ KLLEASTQFQ KKQGKNTIDV 1020
WWLFDDGGLT LLIPYLLTTK KKWKDCKIRV FIGGKINRID HDRRAMATLL SKFRIDFSDI 1080
MVLGDINTKP KKENIIAFDD MIEPYRLHED DKEQDIADKM KEDEPWRITD NELELYKTKT 1140
YRQIRLNELL KEHSSTANII VMSLPVARKG AVSSALYMAW LEALSKDLPP VLLVRGNHQS 1200
VLTFYS 1206 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0051739; F:ammonia transmembrane transporter activity; IEA:Compara.
 GO:0015377; F:cation:chloride symporter activity; IEA:InterPro.
 GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.
 GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:MGI.
 GO:0060763; P:mammary duct terminal end bud growth; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0070634; P:transepithelial ammonium transport; IEA:Compara.
 GO:0030321; P:transepithelial chloride transport; IEA:Compara. 
Interpro
 IPR004841; AA-permease_dom.
 IPR013612; AA_permease_N.
 IPR002443; Na/K/Cl_cotranspt.
 IPR002444; Na/K/Cl_cotranspt1.
 IPR004842; Na/K/Cl_cotransptS. 
Pfam
 PF00324; AA_permease
 PF08403; AA_permease_N 
SMART
  
PROSITE
  
PRINTS
 PR01207; NAKCLTRNSPRT.
 PR01208; NAKCLTRSPRT1.