CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002154
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium channel protein type 1 subunit alpha 
Protein Synonyms/Alias
 Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1 
Gene Name
 Scn1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
453QMLEQLKKQQEAAQQubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. 
Sequence Annotation
 REPEAT 110 454 I.
 REPEAT 750 1022 II.
 REPEAT 1200 1514 III.
 REPEAT 1523 1821 IV.
 DOMAIN 1915 1944 IQ.
 CARBOHYD 211 211 N-linked (GlcNAc...) (Potential).
 CARBOHYD 284 284 N-linked (GlcNAc...) (Potential).
 CARBOHYD 295 295 N-linked (GlcNAc...) (Potential).
 CARBOHYD 301 301 N-linked (GlcNAc...) (Potential).
 CARBOHYD 306 306 N-linked (GlcNAc...) (Potential).
 CARBOHYD 338 338 N-linked (GlcNAc...) (Potential).
 CARBOHYD 601 601 N-linked (GlcNAc...) (Potential).
 CARBOHYD 621 621 N-linked (GlcNAc...) (Potential).
 CARBOHYD 681 681 N-linked (GlcNAc...) (Potential).
 CARBOHYD 892 892 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1060 1060 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1064 1064 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1080 1080 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1146 1146 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1378 1378 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1392 1392 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1403 1403 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2009 AA 
Protein Sequence
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK PNSDLEAGKN 60
LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPFNPLRKI 120
AIKILVHSLF SMLIMCTILT NCVFMTMSNP PDWTKNVEYT FTGIYTFESL IKIIARGFCL 180
EDFTFLRDPW NWLDFTVITF AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 240
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNVTTDY 300
NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM CVKAGRNPNY 360
GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM IFFVLVIFLG SFYLINLILA 420
VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ LKKQQEAAQQ AAAATASEHS REPSAAGRLS 480
DSSSEASKLS SKSAKERRNR RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG 540
NRLTYEKRYS SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED 600
NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAGLPANGK MHSTVDCNGV VSLVGGPSVP 660
TSPVGQLLPE VIIDKPATDD NGTTTETEMR KRRSSSFHVS MDFLEDPSQR QRAMSIASIL 720
TNTVEELEES RQKCPPCWYK FSNIFLIWDC SPYWLKVKHI VNLVVMDPFV DLAITICIVL 780
NTLFMAMEHY PMTEHFNHVL TVGNLVFTGI FTAEMFLKII AMDPYYYFQE GWNIFDGFIV 840
TLSLVELGLA NVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII 900
VFIFAVVGMQ LFGKSYKDCV CKIATDCKLP RWHMNDFFHS FLIVFRVLCG EWIETMWDCM 960
EVAGQAMCLT VFMMVMVIRN LVVLNLFLAL LLSSFSADNL AATDDDNEMN NLQIAVDRMH 1020
KGVAYVKRKI YEFIQQSFVR KQKILDEIKP LDDLNNRKDN CTSNHTTEIG KDLDCLKDVN 1080
GTTSGIGTGS SVEKYIIDES DYMSFINNPS LTVTVPIAVG ESDFENLNTE DFSSESDLEE 1140
SKEKLNESSS SSEGSTVDIG APAEEQPVME PEETLEPEAC FTEGCVQRFK CCQISVEEGR 1200
GKQWWNLRRT CFRIVEHNWF ETFIVFMILL SSGALAFEDI YIDQRKTIKT MLEYADKVFT 1260
YIFILEMLLK WVAYGYQTYF TNAWCWLDFL IVDVSLVSLT ANALGYSELG AIKSLRTLRA 1320
LRPLRALSRF EGMRVVVNAL LGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCVNTT 1380
TGDTFEITEV NNHSDCLKLI ERNETARWKN VKVNFDNVGF GYLSLLQVAT FKGWMDIMYA 1440
AVDSRNVELQ PKYEESLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM 1500
TEEQKKYYNA MKKLGSKKPQ KPIPRPGNKF QGMVFDFVTR QVFDISIMIL ICLNMVTMMV 1560
ETDDQSDYVT SILSRINLVF IVLFTGECVL KLISLRHYYF TIGWNIFDFV VVILSIVGMF 1620
LAELIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV 1680
MFIYAIFGMS NFAYVKREVG IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSKPPD 1740
CDPNKVNPGS SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL 1800
SEDDFEMFYE VWEKFDPDAT QFMEFEKLSQ FAAALEPPLN LPQPNKLQLI AMDLPMVSGD 1860
RIHCLDILFA FTKRVLGESG EMDALRIQME ERFMASNPSK VSYQPITTTL KRKQEEVSAV 1920
IIQRAYRRHL LKRTVKQASF TYNKNKLKGG ANLLVKEDMI IDRINENSIT EKTDLTMSTA 1980
ACPPSYDRVT KPIVEKHEQE GKDEKAKGK 2009 
Gene Ontology
 GO:0001518; C:voltage-gated sodium channel complex; IDA:RGD.
 GO:0030018; C:Z disc; ISS:BHF-UCL.
 GO:0031402; F:sodium ion binding; IDA:RGD.
 GO:0005248; F:voltage-gated sodium channel activity; IDA:RGD.
 GO:0019228; P:regulation of action potential in neuron; IDA:RGD. 
Interpro
 IPR024583; DUF3451.
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR008051; Na_channel_a1su.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF11933; DUF3451
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ 
PRINTS
 PR00170; NACHANNEL.
 PR01664; NACHANNEL1.