CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037976
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 T-cell surface glycoprotein CD3 epsilon chain 
Protein Synonyms/Alias
  
Gene Name
 CD3E 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67IGGDEDDKNIGSDEDubiquitination[1]
79DEDHLSLKEFSELEQubiquitination[1]
98VCYPRGSKPEDANFYubiquitination[1, 2]
171GRQRGQNKERPPPVPubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 201 AA 
Protein Sequence
MQSGTHWRVL GLCLLSVGVW GQDGNEEMAY KVSISGTTVI LTCPQYPGSE ILWQHNDKNI 60
GGDEDDKNIG SDEDHLSLKE FSELEQSGYY VCYPRGSKPE DANFYLYLRA RVCENCMEMD 120
VMSVATIVIV DICITGGLLL LVYYWSKNRK AKAKPVTRGA GAGGRQRGQN KERPPPVPNP 180
DYEPIRKGQR DLYSGLNQRR I 201 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR015477; CD3_epsilon.
 IPR013783; Ig-like_fold.
 IPR003598; Ig_sub2.
 IPR003110; Phos_immunorcpt_sig_ITAM. 
Pfam
 PF02189; ITAM 
SMART
 SM00408; IGc2
 SM00077; ITAM 
PROSITE
 PS51055; ITAM_1 
PRINTS