Tag | Content |
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CPLM ID | CPLM-000349 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein transport protein Sec16A |
Protein Synonyms/Alias | SEC16 homolog A |
Gene Name | SEC16A |
Gene Synonyms/Alias | KIAA0310; SEC16; SEC16L |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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1135 | AFGDRPEKRDNNWRY | ubiquitination | [1] | 1595 | NHSLPFLKFATNEAI | ubiquitination | [1] | 1685 | RLFDPQLKEKPEEES | ubiquitination | [1] | 1687 | FDPQLKEKPEEESLA | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. |
Sequence Annotation | REGION 924 1227 Required for endoplasmic reticulum REGION 1928 2179 Required for interaction with SEC23A. MOD_RES 136 136 Phosphoserine. MOD_RES 391 391 Phosphoserine. MOD_RES 411 411 Phosphoserine. MOD_RES 414 414 Phosphoserine. MOD_RES 415 415 Phosphothreonine. MOD_RES 417 417 Phosphoserine. MOD_RES 891 891 Phosphoserine. MOD_RES 1149 1149 Phosphoserine. MOD_RES 1178 1178 Phosphoserine. MOD_RES 1181 1181 Phosphoserine. MOD_RES 1184 1184 Phosphoserine. MOD_RES 1786 1786 Phosphoserine. MOD_RES 1844 1844 Phosphoserine. MOD_RES 1864 1864 Phosphoserine. MOD_RES 1876 1876 Phosphothreonine. MOD_RES 1895 1895 Phosphoserine. MOD_RES 1905 1905 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2179 AA |
Protein Sequence | MPGLDRPLSR QNPHDGVVTP AASPSLPQPG LQMPGQWGPV QGGPQPSGQH RSPCPEGPVP 60 SGVPCATSVP HFPTPSILHQ GPGHEQHSPL VAPPAALPSD GRDEVSHLQS GSHLANNSDP 120 ESTFRQNPRI VNHWASPELR QNPGVKNEHR PASALVNPLA RGDSPENRTH HPLGAGAGSG 180 CAPLEADSGA SGALAMFFQG GETENEENLS SEKAGLSGQA DFDDFCSSPG LGRPPAPTHV 240 GAGSLCQALL PGPSNEAAGD VWGDTASTGV PDASGSQYEN VENLEFVQNQ EVLPSEPLNL 300 DPSSPSDQFR YGPLPGPAVP RHGAVCHTGA PDATLHTVHP DSVSSSYSSR SHGRLSGSAR 360 PQELVGTFIQ QEVGKPEDEA SGSFFKQIDS SPVGGETDET TVSQNYRGSV SQPSTPSPPK 420 PTGIFQTSAN SSFEPVKSHL VGVKPFEADR ANVVGEVRET CVRQKQCRPA AALPDASPGN 480 LEQPPDNMET LCAPQVCPLP LNSTTEAVHM LPHAGAPPLD TVYPAPEKRP SARTQGPVKC 540 ESPATTLWAQ SELPDFGGNV LLAPAAPALY VCAKPQPPVV QPPEEAMSGQ QSRNPSSAAP 600 VQSRGGIGAS ENLENPPKMG EEEALQSQAS SGYASLLSSP PTESLQNPPV LIAQPDHSYN 660 LAQPINFSVS LSNSHEKNQS WREALVGDRP AVSSWALGGD SGENTSLSGI PTSSVLSLSL 720 PSSVAQSNFP QGSGASEMVS NQPANLLVQP PSQPVPENLV PESQKDRKAG SALPGFANSP 780 AGSTSVVLVP PAHGTLVPDG NKANHSSHQE DTYGALDFTL SRTLENPVNV YNPSHSDSLA 840 SQQSVASHPR QSGPGAPNLD RFYQQVTKDA QGQPGLERAQ QELVPPQQQA SPPQLPKAMF 900 SELSNPESLP AQGQAQNSAQ SPASLVLVDA GQQLPPRPPQ SSSVSLVSSG SGQAAVPSEQ 960 PWPQPVPALA PGPPPQDLAA YYYYRPLYDA YQPQYSLPYP PEPGAASLYY QDVYSLYEPR 1020 YRPYDGAASA YAQNYRYPEP ERPSSRASHS SERPPPRQGY PEGYYSSKSG WSSQSDYYAS 1080 YYSSQYDYGD PGHWDRYHYS ARVRDPRTYD RRYWCDAEYD AYRREHSAFG DRPEKRDNNW 1140 RYDPRFTGSF DDDPDPHRDP YGEEVDRRSV HSEHSARSLH SAHSLASRRS SLSSHSHQSQ 1200 IYRSHNVAAG SYEAPLPPGS FHGDFAYGTY RSNFSSGPGF PEYGYPADTV WPAMEQVSSR 1260 PTSPEKFSVP HVCARFGPGG QLIKVIPNLP SEGQPALVEV HSMEALLQHT SEQEEMRAFP 1320 GPLAKDDTHK VDVINFAQNK AMKCLQNENL IDKESASLLW NFIVLLCRQN GTVVGTDIAE 1380 LLLRDHRTVW LPGKSPNEAN LIDFTNEAVE QVEEEESGEA QLSFLTGGPA AAASSLERET 1440 ERFRELLLYG RKKDALESAM KNGLWGHALL LASKMDSRTH ARVMTRFANS LPINDPLQTV 1500 YQLMSGRMPA ASTCCGDEKW GDWRPHLAMV LSNLNNNMDV ESRTMATMGD TLASRGLLDA 1560 AHFCYLMAQA GFGVYTKKTT KLVLIGSNHS LPFLKFATNE AIQRTEAYEY AQSLGAETCP 1620 LPSFQVFKFI YSCRLAEMGL ATQAFHYCEA IAKSILTQPH LYSPVLISQL VQMASQLRLF 1680 DPQLKEKPEE ESLAAPTWLV HLQQVERQIK EGAGVWHQDG ALPQQCPGTP SSEMEQLDRP 1740 GLSQPGALGI ANPLLAVPAP SPEHSSPSVR LLPSAPQTLP DGPLASPARV PMFPVPLPPG 1800 PLEPGPGCVT PGPALGFLEP SGPGLPPGVP PLQERRHLLQ EARSPDPGIV PQEAPVGNSL 1860 SELSEENFDG KFANLTPSRT VPDSEAPPGW DRADSGPTQP PLSLSPAPET KRPGQAAKKE 1920 TKEPKKGESW FFRWLPGKKK TEAYLPDDKN KSIVWDEKKN QWVNLNEPEE EKKAPPPPPT 1980 SMPKTVQAAP PALPGPPGAP VNMYSRRAAG TRARYVDVLN PSGTQRSEPA LAPADFVAPL 2040 APLPIPSNLF VPTPVSSVRP QGRSGRNDGL LALSSPDAEE PQLPDGTGRE GPAAARGLAN 2100 PEPAPEPKVL SSAASLPGSE LPSSRPEGSQ GGELSRCSSM SSLSREVSQH FNQAPGDLPA 2160 AGGPPSGAMP FYNPAQLAQA CATSGSSRLG RIGQRKHLVL N 2201 |
Gene Ontology | GO:0005829; C:cytosol; IDA:UniProtKB. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0048208; P:COPII vesicle coating; IEA:InterPro. GO:0007029; P:endoplasmic reticulum organization; IDA:UniProtKB. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
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