CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030876
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein-glutamine gamma-glutamyltransferase 2 
Protein Synonyms/Alias
 cDNA FLJ58187, highly similar to Protein-glutamine gamma-glutamyltransferase 2(EC 2.3.2.13) 
Gene Name
 TGM2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
509YLENPEIKIRILGEPacetylation[1]
568VEAGEEVKVRMDLLPacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
 ACT_SITE 196 196 By similarity.
 ACT_SITE 254 254 By similarity.
 ACT_SITE 277 277 By similarity.
 METAL 317 317 Calcium (By similarity).
 METAL 319 319 Calcium (By similarity).
 METAL 366 366 Calcium (By similarity).
 METAL 371 371 Calcium (By similarity).  
Keyword
 Calcium; Complete proteome; Metal-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 606 AA 
Protein Sequence
MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY EASVDSLTFS 60
VVTADAVYLD SEEERQEYVL TQQGFIYQGS AKFIKNIPWN FGQFEDGILD ICLILLDVNP 120
KFLKNAGRDC SRRSSPVYVG RVVSGMVNCN DDQGVLLGRW DNNYGDGVSP MSWIGSVDIL 180
RRWKNHGCQR VKYGQCWVFA AVACTVLRCL GIPTRVVTNY NSAHDQNSNL LIEYFRNEFG 240
EIQGDKSEMI WNFHCWVESW MTRPDLQPGY EGWQALDPTP QEKSEGTYCC GPVPVRAIKE 300
GDLSTKYDAP FVFAEVNADV VDWIQQDDGS VHKSINRSLI VGLKISTKSV GRDEREDITH 360
TYKYPEGSSE EREAFTRANH LNKLAEKEET GMAMRIRVGQ SMNMGSDFDV FAHITNNTAE 420
EYVCRLLLCA RTVSYNGILG PECGTKYLLN LNLEPFSEKS VPLCILYEKY RDCLTESNLI 480
KVRALLVEPV INSYLLAERD LYLENPEIKI RILGEPKQKR KLVAEVSLQN PLPVALEGCT 540
FTVEGAGLTE EQKTVEIPDP VEAGEEVKVR MDLLPLHMGL HKLVVNFESD KLKAVKGFRN 600
VIIGPA 606 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
 GO:0018149; P:peptide cross-linking; IEA:InterPro. 
Interpro
 IPR023608; Gln_gamma-glutamylTfrase_euk.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002931; Transglutaminase-like.
 IPR008958; Transglutaminase_C.
 IPR013808; Transglutaminase_CS.
 IPR001102; Transglutaminase_N. 
Pfam
 PF00927; Transglut_C
 PF01841; Transglut_core
 PF00868; Transglut_N 
SMART
 SM00460; TGc 
PROSITE
 PS00547; TRANSGLUTAMINASES 
PRINTS