UniProt Accession

 ARY2_MOUSE; P50295 

Genbank Protein ID

 U35886; U35887; U37249; U37250 

Genbank Nucleotide ID

 AAA78943.1; AAA78944.1; AAA80353.1; AAA80354.1 

Protein Name

 Arylamine N-acetyltransferase 2 

Protein Synonyms/Alias

 Arylamide acetylase 2; N-acetyltransferase type 2; NAT-2 

Gene Name

 Nat2 

Gene Synonyms/Alias

 Aac2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
247	TYRRFSYKDNVDLVE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Participates in the detoxification of a plethora of hydrazine and arylamine drugs. 2-aminofluorene and p-aminobenzoic acid (PABA) are preferred substrates for NAT-2. Less activity with anisidine and barely detectable with SMZ. 

Sequence Annotation

 REGION 106 107 Substrate binding (By similarity).
 ACT_SITE 68 68 Acyl-thioester intermediate (By
 ACT_SITE 107 107 By similarity.
 ACT_SITE 122 122 By similarity.
 BINDING 103 103 Coenzyme A (By similarity).
 BINDING 104 104 Coenzyme A; via amide nitrogen (By
 BINDING 208 208 Coenzyme A (By similarity).
 MOD_RES 246 246 Phosphotyrosine.  

Keyword

 Acyltransferase; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 290 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004060; F:arylamine N-acetyltransferase activity; IDA:MGI. 

Interpro

 IPR001447; Arylamine_N-AcTrfase. 

Pfam

 PF00797; Acetyltransf_2 

SMART

  

PROSITE

  

PRINTS

 PR01543; ANATRNSFRASE.