CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glia maturation factor beta 
Protein Synonyms/Alias
  
Gene Name
 GMFB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37LRKFRFRKETNNAAIubiquitination[1]
47NNAAIIMKIDKDKRLubiquitination[2]
70GISPDELKDELPERQubiquitination[3]
87TFIVYSYKYQHDDGRubiquitination[2]
110FSSPVGCKPEQQMMYubiquitination[4, 5]
123MYAGSKNKLVQTAELubiquitination[4]
132VQTAELTKVFEIRNTubiquitination[1, 2, 4, 5, 6]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 150 AA 
Protein Sequence
MNKFVGLSNV DPKSESLVVC DVAEDLVEKL RKFRFRKETN NAAIIMKIDK DKRLVVLDEE 60
LEGISPDELK DELPERQPRT FIVYSYKYQH DDGRVSYPLC FIFSSPVGCK PEQQMMYAGS 120
KNKLVQTAEL TKVFEIRNTE DLTEEWLREK 150 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro. 
Interpro
 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR011171; GMF-beta. 
Pfam
 PF00241; Cofilin_ADF 
SMART
 SM00102; ADF 
PROSITE
 PS51263; ADF_H 
PRINTS