| Tag | Content |
|---|
| CPLM ID | CPLM-018515 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mannan-binding lectin serine protease 2 |
Protein Synonyms/Alias | MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2; Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain |
Gene Name | Masp2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | VSPGFPEKYADHQDR | ubiquitination | [1] | | 578 | AGWGLTQKGLLARNL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase (By similarity). |
Sequence Annotation | DOMAIN 20 137 CUB 1.
DOMAIN 138 181 EGF-like; calcium-binding.
DOMAIN 184 296 CUB 2.
DOMAIN 298 363 Sushi 1.
DOMAIN 364 431 Sushi 2.
DOMAIN 444 683 Peptidase S1.
ACT_SITE 483 483 Charge relay system (By similarity).
ACT_SITE 532 532 Charge relay system (By similarity).
ACT_SITE 632 632 Charge relay system (By similarity).
METAL 67 67 Calcium 1 (By similarity).
METAL 75 75 Calcium 1 (By similarity).
METAL 120 120 Calcium 1 (By similarity).
METAL 122 122 Calcium 1; via carbonyl oxygen (By
METAL 123 123 Calcium 1 (By similarity).
METAL 138 138 Calcium 2 (By similarity).
METAL 141 141 Calcium 2 (By similarity).
METAL 158 158 Calcium 2 (By similarity).
METAL 162 162 Calcium 2; via carbonyl oxygen (By
MOD_RES 158 158 (3R)-3-hydroxyasparagine (Potential).
CARBOHYD 103 103 N-linked (GlcNAc...) (Potential).
CARBOHYD 285 285 N-linked (GlcNAc...) (Potential).
CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
CARBOHYD 545 545 N-linked (GlcNAc...) (Potential).
CARBOHYD 641 641 N-linked (GlcNAc...).
DISULFID 72 90 By similarity.
DISULFID 142 156 By similarity.
DISULFID 152 165 By similarity.
DISULFID 167 180 By similarity.
DISULFID 184 211 By similarity.
DISULFID 241 259 By similarity.
DISULFID 300 348 By similarity.
DISULFID 328 361 By similarity.
DISULFID 366 411 By similarity.
DISULFID 396 429 By similarity.
DISULFID 433 552 Interchain (between A and B chains) (By
DISULFID 598 617 By similarity.
DISULFID 628 659 By similarity. |
Keyword | Alternative splicing; Autocatalytic cleavage; Calcium; Complement pathway; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Hydrolase; Hydroxylation; Immunity; Innate immunity; Metal-binding; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Sushi. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 685 AA |
Protein Sequence | MRLLIFLGLL WSLVATLLGS KWPEPVFGRL VSPGFPEKYA DHQDRSWTLT APPGYRLRLY 60
FTHFDLELSY RCEYDFVKLS SGTKVLATLC GQESTDTEQA PGNDTFYSLG PSLKVTFHSD 120
YSNEKPFTGF EAFYAAEDVD ECRVSLGDSV PCDHYCHNYL GGYYCSCRAG YVLHQNKHTC 180
SALCSGQVFT GRSGYLSSPE YPQPYPKLSS CTYSIRLEDG FSVILDFVES FDVETHPEAQ 240
CPYDSLKIQT DKGEHGPFCG KTLPPRIETD SHKVTITFAT DESGNHTGWK IHYTSTARPC 300
PDPTAPPNGS ISPVQAIYVL KDRFSVFCKT GFELLQGSVP LKSFTAVCQK DGSWDRPMPE 360
CSIIDCGPPD DLPNGHVDYI TGPEVTTYKA VIQYSCEETF YTMSSNGKYV CEADGFWTSS 420
KGEKLPPVCE PVCGLSTHTI GGRIVGGQPA KPGDFPWQVL LLGQTTAAAG ALIHDNWVLT 480
AAHAVYEKRM AASSLNIRMG ILKRLSPHYT QAWPEEIFIH EGYTHGAGFD NDIALIKLKN 540
KVTINGSIMP VCLPRKEAAS LMRTDFTGTV AGWGLTQKGL LARNLMFVDI PIADHQKCTA 600
VYEKLYPGVR VSANMLCAGL ETGGKDSCRG DSGGALVFLD NETQRWFVGG IVSWGSINCG 660
AADQYGVYTK VINYIPWIEN IISNF 685 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004252; F:serine-type endopeptidase activity; IEA:Compara. GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW. GO:0001867; P:complement activation, lectin pathway; IEA:Compara. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |