| Tag | Content |
|---|
| CPLM ID | CPLM-014974 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | G-protein-signaling modulator 1 |
Protein Synonyms/Alias | Activator of G-protein signaling 3 |
Gene Name | Gpsm1 |
Gene Synonyms/Alias | Ags3; C10a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 149 | GNLGNTLKVLGRFDE | ubiquitination | [1] | | 383 | QALTFAKKHLQISQE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. |
Sequence Annotation | REPEAT 28 61 TPR 1.
REPEAT 66 99 TPR 2.
REPEAT 106 139 TPR 3.
REPEAT 146 178 TPR 4.
REPEAT 180 199 TPR 5.
REPEAT 206 239 TPR 6.
REPEAT 246 279 TPR 7.
REPEAT 286 319 TPR 8.
REPEAT 326 359 TPR 9.
DOMAIN 493 515 GoLoco 1.
DOMAIN 546 568 GoLoco 2.
DOMAIN 594 616 GoLoco 3.
DOMAIN 628 650 GoLoco 4.
REGION 1 507 Mediates association with membranes (By
REGION 361 485 Interaction with STK11/LKB1 (By
MOD_RES 410 410 Phosphoserine (By similarity).
MOD_RES 469 469 Phosphoserine (By similarity).
MOD_RES 490 490 Phosphoserine (By similarity).
MOD_RES 491 491 Phosphoserine (By similarity).
MOD_RES 653 653 Phosphoserine. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Membrane; Neurogenesis; Phosphoprotein; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 673 AA |
Protein Sequence | MLASAMEGQP LALSLAEKAV CKVVYGAPRP RPLLLPVGLE LWLYVQKMRN LQRKRMEASC 60
LELALEGERL CKAGDFKAGV AFFEAAVQVG TEDLKTLSAI YSQLGNAYFY LKEYARALQF 120
HKHDLLLART IGDRMGEAKA SGNLGNTLKV LGRFDEAIVC CQRHLDIAQE QGDKVGEARA 180
LYNIGNVYHA KGKQLSWNAA QDPGHLPPDV RETLHRASEF YERNLSLVKE LGDRAAQGRA 240
YGNLGNTHYL LGNFTEATTF HKERLAIAKE FGDKAAERRA YSNLGNAHIF LGRFDVAAEH 300
YKKTLQLSRQ LRDQAVEAQA CYSLGNTYTL LQDYERAAEY HLRHLVIAQE LADRVGEGRA 360
CWSLGNAYVS MGSPAQALTF AKKHLQISQE IGDRNGELTA RMNIAHLQLA LGRLTSPAAA 420
EKPDLAGYEA QGARPKRTQR LSAETWDLLR LPLDREQNGE THHTGDWRGP GRDSLPLPMR 480
SRKYQEGPDA IERRPREGSH SPLDSADVRV QVPRTGIPRA PSSDEECFFD LLSKFQSSRM 540
DDQRCPLEEG QAGAAEATAA PSVEDRAAQS SVTASPQTEE FFDLIASSQS RRLDDQRASV 600
GSLPGLRITL NNVGHLRGDG DAQEPGDEFF NMLIKYQSSR IDDQRCPPPD VLPRGPTMPD 660
EDFFSLIQRV QAKRMDEQRV DLAGSPEQEA SGLPDPQQQC PPGAS 705 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005092; F:GDP-dissociation inhibitor activity; IEA:InterPro. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0007399; P:nervous system development; IEA:UniProtKB-KW. GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |