UniProt Accession

 EDC3_HUMAN; Q96F86; B3KPH0; D3DW61; Q9H797 

Genbank Protein ID

 AF193058; AK024781; AK056339; CH471136; CH471136; CH471136; CH471136; BC011534; BC021271 

Genbank Nucleotide ID

 AAG22486.1; BAB15001.1; BAG51682.1; EAW99316.1; EAW99317.1; EAW99318.1; EAW99319.1; AAH11534.1; AAH21271.1 

Protein Name

 Enhancer of mRNA-decapping protein 3 

Protein Synonyms/Alias

 LSM16 homolog; YjeF N-terminal domain-containing protein 2; YjeF_N2; hYjeF_N2; YjeF domain-containing protein 1 

Gene Name

 EDC3 

Gene Synonyms/Alias

 LSM16; YJDC; YJEFN2; PP844 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
269	IVPHNVSKEFCTDSG	ubiquitination	[1]
289	ISYELHKKLLSVAEK	ubiquitination	[1]
296	KLLSVAEKHGLTLER	ubiquitination	[1]
387	NELSLFSKTQGQQVS	ubiquitination	[1]
426	LRDQPWYKAAVAWAN	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis. 

Sequence Annotation

 DOMAIN 192 228 DFDF.
 DOMAIN 283 487 YjeF N-terminal.
 REGION 1 79 Required for P-body targeting and
 REGION 191 296 Required for interaction with DDX6 (By
 MOD_RES 131 131 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 140 140 Phosphoserine.
 MOD_RES 161 161 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 508 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome. 

Interpro

 IPR025762; DFDF.
 IPR019050; FDF_dom.
 IPR025609; Lsm14_N.
 IPR004443; YjeF_N_dom. 

Pfam

 PF09532; FDF
 PF12701; LSM14
 PF03853; YjeF_N 

SMART

  

PROSITE

 PS51512; DFDF
 PS51385; YJEF_N 

PRINTS