CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019479
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 14 
Protein Synonyms/Alias
 TPR repeat protein 14 
Gene Name
 TTC14 
Gene Synonyms/Alias
 KIAA1980; UNQ5813/PRO19630 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66VDNIEIQKFISKKADubiquitination[1]
70EIQKFISKKADLLFAubiquitination[1]
287LMRGLQSKNFSEDDFubiquitination[1, 2, 3]
301FASALRKKQSASWALubiquitination[1]
319KIGVDYFKVGRHVDAubiquitination[1]
332DAMNEYNKALEIDKQubiquitination[1]
338NKALEIDKQNVEALVubiquitination[1, 3]
354RGALYATKGSLNKAIubiquitination[1]
359ATKGSLNKAIEDFELubiquitination[1]
407NAESYYKKALALDETubiquitination[1]
431KLHKYMQKSLELREKubiquitination[1]
460TSAEKLRKLLKEEKRubiquitination[1]
568QDRLQYEKTQIKEKDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 DOMAIN 126 208 S1 motif.
 REPEAT 210 243 TPR 1.
 REPEAT 307 340 TPR 2.
 REPEAT 342 374 TPR 3.
 REPEAT 382 415 TPR 4.
 MOD_RES 671 671 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 770 AA 
Protein Sequence
MDRDLLRQSL NCHGSSLLSL LRSEQQDNPH FRSLLGSAAE PARGPPPQHP LQGRKEKRVD 60
NIEIQKFISK KADLLFALSW KSDAPATSEI NEDSEDHYAI MPPLEQFMEI PSMDRRELFF 120
RDIERGDIVI GRISSIREFG FFMVLICLGS GIMRDIAHLE ITALCPLRDV PSHSNHGDPL 180
SYYQTGDIIR AGIKDIDRYH EKLAVSLYSS SLPPHLSGIK LGVISSEELP LYYRRSVELN 240
SNSLESYENV MQSSLGFVNP GVVEFLLEKL GIDESNPPSL MRGLQSKNFS EDDFASALRK 300
KQSASWALKC VKIGVDYFKV GRHVDAMNEY NKALEIDKQN VEALVARGAL YATKGSLNKA 360
IEDFELALEN CPTHRNARKY LCQTLVERGG QLEEEEKFLN AESYYKKALA LDETFKDAED 420
ALQKLHKYMQ KSLELREKQA EKEEKQKTKK IETSAEKLRK LLKEEKRLKK KRRKSTSSSS 480
VSSADESVSS SSSSSSSGHK RHKKHKRNRS ESSRSSRRHS SRASSNQIDQ NRKDECYPVP 540
ANTSASFLNH KQEVEKLLGK QDRLQYEKTQ IKEKDRCPLS SSSLEIPDDF GGRSEDPRDF 600
YNSYKTQAGS SKTEKPYKSE RHFSSRRNSS DSFCRNSEDK IYGYRRFEKD IEGRKEHYRR 660
WEPGSVRHST SPASSEYSWK SVEKYKKYAH SGSRDFSRHE QRYRLNTNQG EYEREDNYGE 720
DIKTEVPEED ALSSKEHSES SVKKNLPQNL LNIFNQIAEF EKEKGNKSKN 770 
Gene Ontology
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR012340; NA-bd_OB-fold.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR022967; RNA-binding_domain_S1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
  
SMART
 SM00316; S1
 SM00028; TPR 
PROSITE
 PS50126; S1
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS