UniProt Accession

 CYTC_MOUSE; P21460; Q544Y0 

Genbank Protein ID

 M59470; U10098; AF483486; AF483487; AK002438; AK013676; AK014368; AK131728; AK146333; AK151160; AK161856; AK166430; BC002072 

Genbank Nucleotide ID

 AAA63298.1; AAB41056.1; AAL90760.1; AAL90761.1; BAB22101.1; BAB28949.1; BAB29303.1; BAE20785.1; BAE27088.1; BAE30165.1; BAE36608.1; BAE38771.1; AAH02072.1 

Protein Name

 Cystatin-C 

Protein Synonyms/Alias

 Cystatin-3 

Gene Name

 Cst3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
56	FAVSEYNKGSNDAYH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. 

Sequence Annotation

 MOTIF 75 79 Secondary area of contact.
 DISULFID 93 103 By similarity.
 DISULFID 117 137 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Protease inhibitor; Reference proteome; Secreted; Signal; Thiol protease inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0042995; C:cell projection; IEA:Compara.
 GO:0043292; C:contractile fiber; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0005771; C:multivesicular body; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0001540; F:beta-amyloid binding; IEA:Compara.
 GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0001775; P:cell activation; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0042747; P:circadian sleep/wake cycle, REM sleep; IEA:Compara.
 GO:0006952; P:defense response; IEA:Compara.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0043206; P:extracellular fibril organization; IEA:Compara.
 GO:0001654; P:eye development; IEA:Compara.
 GO:0060313; P:negative regulation of blood vessel remodeling; IEA:Compara.
 GO:0060548; P:negative regulation of cell death; IEA:Compara.
 GO:0010711; P:negative regulation of collagen catabolic process; IEA:Compara.
 GO:0060311; P:negative regulation of elastin catabolic process; IEA:Compara.
 GO:0010716; P:negative regulation of extracellular matrix disassembly; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0043067; P:regulation of programmed cell death; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0009743; P:response to carbohydrate stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0007431; P:salivary gland development; IEA:Compara.
 GO:0060009; P:Sertoli cell development; IEA:Compara. 

Interpro

 IPR027214; Cystatin.
 IPR000010; Prot_inh_cystat.
 IPR018073; Prot_inh_cystat_CS. 

Pfam

 PF00031; Cystatin 

SMART

 SM00043; CY 

PROSITE

 PS00287; CYSTATIN 

PRINTS