CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021075
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 39S ribosomal protein L46, mitochondrial 
Protein Synonyms/Alias
 L46mt; MRP-L46 
Gene Name
 Mrpl46 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
140ARETEADKKNDRTSLacetylation[1, 2]
141RETEADKKNDRTSLHacetylation[1]
212NAPCGHYKFKFPKAIacetylation[1]
217HYKFKFPKAIQTESDacetylation[3]
217HYKFKFPKAIQTESDsuccinylation[3]
246GDFVQAGKKSRHVWAacetylation[3]
246GDFVQAGKKSRHVWAsuccinylation[3]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
 MOD_RES 228 228 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 283 AA 
Protein Sequence
MAAPVGRTLL GLARGWRQLD RFWAGSSRGL SLEAASSSSR SPWRLSGALC LQRPPLITKA 60
LTPLQEEMAG LLQQIEVERS LYSDHELRAL DEAQRLAKKK ADLYDEEQEQ GITLAQDLED 120
MWEQAFLQFR PGARETEADK KNDRTSLHRK LDRNLVLLVR EKLGDQDVWM LPQVEWQPGE 180
TLRGTAERIL ATLSENNMEA KFLGNAPCGH YKFKFPKAIQ TESDLGVKVF FFKALLLTGD 240
FVQAGKKSRH VWASKEELGD YLQPKYLAQV RRFLLDSDGL SCL 283 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0016787; F:hydrolase activity; IEA:InterPro. 
Interpro
 IPR015797; NUDIX_hydrolase_dom-like.
 IPR021757; Ribosomal_L46. 
Pfam
 PF11788; MRP-L46 
SMART
  
PROSITE
  
PRINTS