UniProt Accession

 K7EJX5_HUMAN; K7EJX5 

Genbank Protein ID

 AC100847 

Genbank Nucleotide ID

  

Protein Name

 Ferrochelatase 

Protein Synonyms/Alias

  

Gene Name

 FECH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
60	YRLVWQSKVGPMPWL	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Catalyzes the ferrous insertion into protoporphyrin IX (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Heme biosynthesis; Iron; Lyase; Porphyrin biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 143 AA 

Protein Sequence

Gene Ontology

 GO:0004325; F:ferrochelatase activity; IEA:EC.
 GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR001015; Ferrochelatase.
 IPR019772; Ferrochelatase_AS. 

Pfam

 PF00762; Ferrochelatase 

SMART

  

PROSITE

 PS00534; FERROCHELATASE 

PRINTS