| Tag | Content |
|---|
| CPLM ID | CPLM-001074 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase UBR1 |
Protein Synonyms/Alias | N-recognin-1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I |
Gene Name | Ubr1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 806 | GLENVINKVATFKKP | ubiquitination | [1] | | 944 | VAFDFYHKASRLGSS | ubiquitination | [1] | | 1584 | CGDPALLKSLKQKSA | ubiquitination | [1] | | 1711 | GETDPGLKRGNPLHL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). |
Sequence Annotation | ZN_FING 97 168 UBR-type.
ZN_FING 1101 1204 RING-type; atypical.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 1182 1182 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Ligase; Metal-binding; Phosphoprotein; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1757 AA |
Protein Sequence | MADEEMDGAE RMDVSPEPPL APQRPASWWD QQVDFYTAFL HHLAQLVPEI YFAEMDPDLE 60
KQEESVQMSI LTPLEWYLFG EDPDICLEKL KHSGAFQLCG KVFKSGETTY SCRDCAIDPT 120
CVLCMDCFQS SVHKNHRYKM HTSTGGGFCD CGDTEAWKTG PFCVDHEPGR AGTTKESLHC 180
PLNEEVIAQA RRIFPSVIKY IVEMTIWEEE KELPPELQIR EKNERYYCVL FNDEHHSYDH 240
VIYSLQRALD CELAEAQLHT TAIDKEGRRA VKAGVYATCQ EAKEDIKSHS ENVSQHPLHV 300
EVLHSVVMAH QKFALRLGSW MNKIMSYSSD FRQIFCQACL VEEPGSENPC LISRLMLWDA 360
KLYKGARKIL HELIFSSFFM EMEYKKLFAM EFVKYYKQLQ KEYISDDHER SISITALSVQ 420
MLTVPTLARH LIEEQNVISV ITETLLEVLP EYLDRNNKFN FQGYSQDKLG RVYAVICDLK 480
YILISKPVIW TERLRAQFLE GFRSFLKILT CMQGMEEIRR QVGQHIEVDP DWEAAIAIQM 540
QLKNILLMFQ EWCACDEDLL LVAYKECHKA VMRCSTNFMS STKTVVQLCG HSLETKSYKV 600
SEDLVSIHLP LSRTLAGLHV RLSRLGAISR LHEFVPFDGF QVEVLVEYPL RCLVLVAQVV 660
AEMWRRNGLS LISQVFYYQD VKCREEMYDK DIIMLQIGAS IMDPNKFLLL VLQRYELTDA 720
FNKTISTKDQ DLIKQYNTLI EEMLQVLIYI VGERYVPGVG NVTREEVIMR EITHLLCIEP 780
MPHSAIARNL PENENNETGL ENVINKVATF KKPGVSGHGV YELKDESLKD FNMYFYHYSK 840
TQHSKAEHMQ KKRRKQENKD EALPPPPPPE FCPAFSKVVN LLSCDVMMYI LRTIFERAVD 900
MESNLWTEGM LQMAFHILAL GLLEEKQQLQ KAPEEEVAFD FYHKASRLGS SAMNAQNIQM 960
LLEKLKGIPQ LESQKDMITW ILQMFDTVKR LREKSCLVVA TTSGLECVKS EEITHDKEKA 1020
ERKRKAEAAR LHRQKIMAQM SALQKNFIET HKLMYDNTSE VTGKEDSIME EESTSAVSEA 1080
SRIALGPKRG PAVTEKEVLT CILCQEEQEV KLENNAMVLS ACVQKSTALT QHRGKPVDHL 1140
GETLDPLFMD PDLAHGTYTG SCGHVMHAVC WQKYFEAVQL SSQQRIHVDL FDLESGEYLC 1200
PLCKSLCNTV IPIIPLQPQK INSENAEALA QLLTLARWIQ TVLARISGYN IKHAKGEAPA 1260
VPVLFNQGMG DSTFEFHSIL SFGVQSSVKY SNSIKEMVIL FATTIYRIGL KVPPDELDPR 1320
VPMMTWSTCA FTIQAIENLL GDEGKPLFGA LQNRQHNGLK ALMQFAVAQR TTCPQVLIHK 1380
HLARLLSVIL PNLQSENTPG LLSVDLFHVL VGAVLAFPSL YWDDTVDLQP SPLSSSYNHL 1440
YLFHLITMAH MLQILLTTDT DLSSGPPLAE GEEDSEEARC ASAFFVEVSQ HTDGLAGCGA 1500
PGWYLWLSLR NGITPYLRCA ALLFHYLLGV APPEELFANS AEGEFSALCS YLSLPTNLFL 1560
LFQEYWDTIR PLLQRWCGDP ALLKSLKQKS AVVRYPRKRN SLIELPEDYS CLLNQASHFR 1620
CPRSADDERK HPVLCLFCGA ILCSQNICCQ EIVNGEEVGA CVFHALHCGA GVCIFLKIRE 1680
CRVVLVEGKA RGCAYPAPYL DEYGETDPGL KRGNPLHLSR ERYRKLHLVW QQHCIIEEIA 1740
RSQETNQMLF GFNWQLL 1757 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0000502; C:proteasome complex; IGI:MGI. GO:0000151; C:ubiquitin ligase complex; IGI:MGI. GO:0070728; F:leucine binding; IEA:Compara. GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0071233; P:cellular response to leucine; ISS:UniProtKB. GO:0032007; P:negative regulation of TOR signaling cascade; ISS:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |